Millipore Sigma Vibrant Logo

MABC1207 Anti-CIRP (CIRBP) Antibody, clone 6C7.1

Detect CIRBP using this mouse monoclonal Anti-CIRP (CIRBP) Antibody, clone 6C7.1, Cat. No. MABC1207, validated for use in Immunohistochemistry (Paraffin) and Western Blotting.

Anti-CIRP (CIRBP) Antibody, clone 6C7.1: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Research Category: Apoptosis & Cancer Gene Symbol: CIRBP, A18HNRNP, CIRP UniProt Number: Q14011
View Products on Sigmaaldrich.com
MABC1207
100 µL  
Recuperando precio...
No pudo obtenerse el precio
La cantidad mínima tiene que ser múltiplo de
Maximum Quantity is
Al finalizar el pedido Más información
Ahorró ()
 
—
Solicitar precio
—
Disponibilidad a confirmar Disponibilidad a confirmar
Ingrese cantidad 
Suspendido
Cantidades limitadas disponibles
Debe confirmarse disponibilidad
    El resto: se avisará
      El resto: se avisará
      Se avisará
      Póngase en contacto con el Servicio de Atención al Cliente
      Contact Customer Service

      Ofertas especiales

       

      Póngase en contacto con el Servicio de Atención al Cliente

      Descripción

      Replacement Information

      Ofertas especiales

      100% Performance Guaranteed

      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RIH(P), WBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABC1207
      DescriptionAnti-CIRP (CIRBP) Antibody, clone 6C7.1
      Alternate Names
      • Cold-inducible RNA-binding protein
      • A18 hnRNP
      • Glycine-rich RNA-binding protein CIRP
      Background InformationCold-inducible RNA-binding protein (UniProt Q14011; also known as A18 hnRNP, Glycine-rich RNA-binding protein CIRP) is encoded by the CIRBP (also known as A18HNRNP, CIRP) gene (Gene ID 1153) in human. CIRP is an 18-kDa RNA-binding protein with an RNA recognition motif (RRM; a.a. 6-84) and a glycine-rich domain (a.a. 92-158). CIRP migrates from nucleus to cytoplasm, where it mediates posttranscriptional regulation of target mRNAs. Originally characterized and named as a cold-induced protein, CIRP exerts antiapoptotic and cell-protective effects in response to cold stress, as well as other stimuli such as UV irradiation and hypoxia. CIRP is expressed in a broad range of tissues (e.g. testis, brain, lung, kidney, liver, stomach, bone marrow, and heart) and upregulated CIRP levels have been reported in several types of cancers. CIRP knockdown is reported to increase p53 level and enhance cancer cells chemo-sensitivity to DNA damage inducing drugs. Likewise, CIRP overexpression results in p53 downregulation.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect CIRBP using this mouse monoclonal Anti-CIRP (CIRBP) Antibody, clone 6C7.1, Cat. No. MABC1207, validated for use in Immunohistochemistry (Paraffin) and Western Blotting.
      Key Applications
      • Immunohistochemistry (Paraffin)
      • Western Blotting
      Application NotesImmunohistochemistry Analysis: A 1:250 dilution from a representative lot detected CIRP (CIRBP) in rat testis and human prostate cancer, pancreas, tonsil tissue sections.

      Western Blotting Analysis: A 1:2,000 dilution from a representative lot detected CIRP (CIRBP) in 10 µg of Raji human B-cell lymphoma cell lysate.
      Biological Information
      ImmunogenGST-tagged recombinant human CIRP (CIRBP) internal fragment.
      Clone6C7.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 6C7.1 is expected to recognize CIRP spliced isoforms 1 and 3 (UniProt Q14011). Cross-reactivity toward spliced isoform 2 is possible, but has not been confirmed.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      • Rat
      Species Reactivity NoteHuman, Rat. Predicted to react with Mouse based on 100% sequence homology.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CIRBP
      • A18HNRNP
      • CIRP
      Purification MethodProtein G purified.
      UniProt Number
      Molecular Weight~18 kDa observed. 18.65/28.36/26.13 kDa (isoform 1/2/3) calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in SH-SY5Y cell lysate.

      Western Blotting Analysis: A 1:2,000 dilution of this antibody detected CIRP (CIRBP) in 10 µg of SH-SY5Y human neuroblastoma cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      MABC1207 04054839069628