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MABC1814-100UG Anti-CD44v6 Antibody, clone C44Mab-9

This mouse monoclonal Anti-CD44v6, clone C44Mab-9, Cat. No. MABC1814 is tested for use in Flow Cytometry, ELISA, Immunohistochemistry, Western Blotting, for the detection of CD44v4.

NuevoMABC1814-100UG
100 μg  
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      Descripción

      Replacement Information
      Description
      Catalogue NumberMABC1814-100UG
      DescriptionAnti-CD44v6 Antibody, clone C44Mab-9
      Alternate Names
      • CDw44
      • Epican
      • Extracellular matrix receptor III (ECMR-III) GP90 lymphocyte homing/adhesion receptor
      • HUTCH-I
      • Heparan sulfate proteoglycan
      • Hermes antigen
      • Hyaluronate receptor
      • Phagocytic glycoprotein 1 (PGP-1)
      • Phagocytic glycoprotein I (PGP-I)
      • LHR
      • MDU2
      • MDU3
      • MIC4
      Background InformationCD44 antigen (UniProt: P16070; also known as CDw44, Epican, Extracellular matrix receptor III (ECMR-III), GP90 lymphocyte homing/adhesion receptor, HUTCH-I, Heparan sulfate proteoglycan, Hermes antigen, Hyaluronate receptor, Phagocytic glycoprotein 1 (PGP-1), Phagocytic glycoprotein I (PGP-I)) is encoded by the CD44 (also known as LHR, MDU2, MDU3, MIC4) gene (Gene ID: 960) in human. CD44 is a Type 1 transmembrane glycoprotein involved in cell adhesion, migration, and proliferation. It also plays a role in lymphocyte activation, tumor metastasis, and wound healing. It is encoded by the CD44 gene, and it is expressed in a wide range of cell types. The protein's structure includes a hyaluronic acid (HA) binding domain, a stem region, and a variable extracellular domain. Alternative splicing may produce 19 isoforms. CD44 splice variants (CD44v) play a role in tumorigenesis and malignancy. It is also implicated in various other diseases, including autoimmune disorders, cardiovascular diseases and fibrosis. (Ref.: Suzuki, H., et al. (2023). Curr Issues Mol Biol. 45(3):1875-1888).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ200
      Applications
      ApplicationThis mouse monoclonal Anti-CD44v6, clone C44Mab-9, Cat. No. MABC1814 is tested for use in Flow Cytometry, ELISA, Immunohistochemistry, Western Blotting, for the detection of CD44v4.
      Key Applications
      • Flow Cytometry
      • ELISA
      • Immunohistochemistry
      • Western Blotting
      Application NotesTested Applications

      Flow Cytometry Analysis: A representative lot detected CD44v4 in Flow Cytometry applications (Ejima, R., et al. (2023). Int. J. Mol. Sci. 24(4):4007).

      Western Blotting Analysis: A representative lot detected CD44v4 in Western Blotting applications (Ejima, R., et al. (2023). Int. J. Mol. Sci. 24(4):4007).

      Immunohistochemistry Applications: A representative lot detected CD44v6 in Immunohistochemistry applications (Ejima, R., et al. (2023). Int. J. Mol. Sci. 24(4):4007).

      ELISA Analysis: A representative lot detected CD44v4 in ELISA applications (Ejima, R., et al. (2023). Int. J. Mol. Sci. 24(4):4007).

      Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user.
      Biological Information
      ImmunogenCHO cells transfected with PA16-tagged CD44v3 10
      EpitopeN-terminal half
      CloneC44Mab-9
      Concentration1.0 mg/mL. Please refer to guidance on suggested starting dilutions and/or titers per application and sample type.
      HostMouse
      SpecificityClone C44Mab-9 is a mouse monoclonal antibody that detects CD44v6. It targets an epitope within 20 amino acids from the N-terminal half of the protein.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CD44
      Purification MethodProtein G purified
      UniProt Number
      Molecular WeightTarget molecular weight 76.71 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in a CHO cells overexpressing CD44v3-10.

      Flow Cytometry Analysis: 1.0 µg of this antibody detected CD44v6 in one million CHO cells overexpressing CD44v3-10.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsRecommended storage: +2°C to +8°C.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      MABC1814-100UG 04065271266544