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MABC1832-25UG Anti-CD44v4 Antibody, clone C44Mab-108

This mouse monoclonal Anti-CD44v4, clone C44Mab-108, Cat. No. MABC1832 is tested for use in Flow Cytometry, Immunohistochemistry, Western Blotting, and ELISA, for the detection of CD44v4.

NuevoMABC1832-25UG
25 μg  
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      Descripción

      Replacement Information
      Description
      Catalogue NumberMABC1832-25UG
      DescriptionAnti-CD44v4 Antibody, clone C44Mab-108
      Alternate Names
      • CDw44
      • Epican
      • Extracellular matrix receptor III (ECMR-III) GP90 lymphocyte homing/adhesion receptor
      • HUTCH-I
      • Heparan sulfate proteoglycan
      • Hermes antigen
      • Hyaluronate receptor
      • Phagocytic glycoprotein 1 (PGP-1)
      • Phagocytic glycoprotein I (PGP-I)
      • LHR
      • MDU2
      • MDU3
      • MIC4
      Background InformationCD44 antigen (UniProt: P16070; also known as CDw44, Epican, Extracellular matrix receptor III (ECMR-III), GP90 lymphocyte homing/adhesion receptor, HUTCH-I, Heparan sulfate proteoglycan, Hermes antigen, Hyaluronate receptor, Phagocytic glycoprotein 1 (PGP-1), Phagocytic glycoprotein I (PGP-I)) is encoded by the CD44 (also known as LHR, MDU2, MDU3, MIC4) gene (Gene ID: 960) in human. CD44 is a Type 1 transmembrane glycoprotein involved in cell adhesion, migration, and proliferation. It also plays a role in lymphocyte activation, tumor metastasis, and wound healing. It is encoded by the CD44 gene, and it is expressed in a wide range of cell types. The protein's structure includes a hyaluronic acid (HA) binding domain, a stem region, and a variable extracellular domain. Alternative splicing may produce 19 isoforms. CD44 splice variants (CD44v) play a role in tumorigenesis and malignancy. It is also implicated in various other diseases, including autoimmune disorders, cardiovascular diseases and fibrosis.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ200
      Applications
      ApplicationThis mouse monoclonal Anti-CD44v4, clone C44Mab-108, Cat. No. MABC1832 is tested for use in Flow Cytometry, Immunohistochemistry, Western Blotting, and ELISA, for the detection of CD44v4.
      Key Applications
      • Flow Cytometry
      • ELISA
      • Western Blotting
      • Immunohistochemistry
      Application NotesTested Applications

      ELISA Analysis: A representative lot detected CD44v4 in ELISA applications (Suzuki, H., et al. (2023). Curr. Issues Mol. Biol. 45(3):1875-1888).

      Western Blotting Analysis: A representative lot detected CD44v4 in Western Blotting applications (Suzuki, H., et al. (2023). Curr. Issues Mol. Biol. 45(3):1875-1888).

      Flow Cytometry Analysis: A representative lot detected CD44v4 in Flow Cytometry applications (Suzuki, H., et al. (2023). Curr Issues Mol Biol. 45(3):1875-1888).

      Immunohistochemistry Applications: A representative lot detected CD44v4 in Immunohistochemistry applications (Suzuki, H., et al. (2023). Curr. Issues Mol. Biol. 45(3):1875-1888).

      Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to 19 amino acids from the N-terminal extracellular domain of human CD44v4.
      EpitopeN-terminal extracellular domain
      CloneC44Mab-108
      Concentration0.5 mg/mL. Please refer to guidance on suggested starting dilutions and/or titers per application and sample type.
      HostMouse
      SpecificityClone C44Mab-108 is a mouse monoclonal antibody that detects CD44v4. It targets an epitope within 19 amino acids from the N-terminal extracellular domain of the protein.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with Monkey based on 100% sequence homology.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CD44
      Purification MethodProtein G purified
      UniProt Number
      Molecular WeightTarget molecular weight 81.54 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in a CHO cells overexpressing CD44v3-10.

      Flow Cytometry Analysis: 1.0 µg of this antibody detected CD44v6 in a one million CHO cells overexpressing CD44v3-10.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsRecommended storage: +2°C to +8°C.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      MABC1832-25UG 04065271270114