Millipore Sigma Vibrant Logo

AB2232 Anti-Atrial Natriuretic Polypetide Antibody, alpha

This Anti-Atrial Natriuretic Polypetide Antibody, alpha is validated for use in WB for the detection of Atrial Natriuretic Polypetide.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Research Category: Neuroscience Research Sub-Category: Neurotransmitters & Receptors Gene Symbol: ANF , ANP, CDD-ANF, OTTHUMP00000002504, OTTHUMP00000044485, PND , Prepronatriodilatin, pronatriodilatin UniProt Number: P01160
View Products on Sigmaaldrich.com
AB2232
100 µg  
Recuperando precio...
No pudo obtenerse el precio
La cantidad mínima tiene que ser múltiplo de
Maximum Quantity is
Al finalizar el pedido Más información
Ahorró ()
 
—
Solicitar precio
—
Disponibilidad a confirmar Disponibilidad a confirmar
Ingrese cantidad 
Suspendido
Cantidades limitadas disponibles
Debe confirmarse disponibilidad
    El resto: se avisará
      El resto: se avisará
      Se avisará
      Póngase en contacto con el Servicio de Atención al Cliente
      Contact Customer Service

      Ofertas especiales

       

      Póngase en contacto con el Servicio de Atención al Cliente

      Descripción

      Replacement Information

      Ofertas especiales

      100% Performance Guaranteed

      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWBRbPurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB2232
      DescriptionAnti-Atrial Natriuretic Polypetide Antibody, alpha
      Alternate Names
      • Atrial natriuretic peptide
      • natriuretic peptide precursor A
      • natriuretic peptide precursor A variant 2
      Background InformationAtrial natriuretic polypeptide, alpha (ANP), atrial natriuretic factor (ANF), or atriopeptin, is a protein (polypeptide) hormone secreted by heart muscle cells. It is involved in the homeostatic control of body water, sodium, potassium and fat (adiposity). It is released by muscle cells in the upper chambers (atria) of the heart (atrial myocytes), in response to high blood pressure. ANP acts to reduce the water, sodium and adipose loads on the circulatory system, thereby reducing blood pressure. ANP binds to a specific set of receptors - ANP receptors. Receptor-agonist binding causes a reduction in blood volume and therefore a reduction in cardiac output and systemic blood pressure. Lipolysis is increased and renal sodium reabsorption is decreased. The overall effect of ANP on the body is to counter increases in blood pressure and volume caused by the renin-angiotensin system (1).
      References
      Product Information
      FormatPurified
      Control
      • Rat Heart
      PresentationPurified in 0.1M Tris-Glycine (pH7.4) 15mM NaCl with 0.05% NaN3
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Atrial Natriuretic Polypetide Antibody, alpha is validated for use in WB for the detection of Atrial Natriuretic Polypetide.
      Key Applications
      • Western Blotting
      Application NotesNon-Lot Specific Tested Application 1:
      Immunohistochemistry:
      1:50-1:500 on paraffin embedded tissue.

      Optimum dilutions need to be determined by the end user.
      Biological Information
      ImmunogenSynthetic Linear Peptide
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityCat. # AB2232 recognizes ANP, alpha
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Species Reactivity NoteRat, Human and Mouse. May react with dog, cat and cow based on sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ANF
      • ANP
      • CDD-ANF
      • OTTHUMP00000002504
      • OTTHUMP00000044485
      • PND
      • Prepronatriodilatin
      • pronatriodilatin
      Purification MethodPurified
      UniProt Number
      UniProt SummaryFUNCTION: A potent vasoactive substance which is thought to play a key role in cardiovascular homeostasis. Has a cGMP-stimulating activity.
      SUBUNIT: Interacts with NPR3.
      LOCATION: Secreted.
      POLYMORPHISM: There are two different prepronatriodilatin alleles. One codes for 2 Arg residues at the C-terminus that are cleaved to form the mature peptide, while the other ends in a termination codon immediately after the last codon of the mature peptide.
      SIMILARITY: Belongs to the natriuretic peptide family.
      Molecular Weight~17 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by western blot
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Handling Recommendations: Prior to removing the cap, gently centrifuge the vial and gently mix the solution.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      AB2232 04053252621215

      Documentation

      Licencias necesarias

      Título
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Anti-Atrial Natriuretic Polypetide Antibody, alpha Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Anti-Atrial Natriuretic Polypetide Antibody, alpha Certificados de análisis

      CargoNúmero de lote
      Anti-Atrial Natriuretic Polypeptide, -2796324 2796324
      Anti-Atrial Natriuretic Polypeptide, alpha - 2117252 2117252
      Anti-Atrial Natriuretic Polypeptide, alpha - 2161143 2161143
      Anti-Atrial Natriuretic Polypeptide, alpha - 2424500 2424500
      Anti-Atrial Natriuretic Polypeptide, alpha - 2455728 2455728
      Anti-Atrial Natriuretic Polypeptide, alpha - 2110005 2110005
      Anti-Atrial Natriuretic Polypeptide, alpha - 2343589 2343589
      Anti-Atrial Natriuretic Polypeptide, alpha - 3856689 3856689
      Anti-Atrial Natriuretic Polypeptide, alpha - NG1809713 NG1809713
      Anti-Atrial Natriuretic Polypeptide, alpha - NG1917782 NG1917782
      Show more

      Referencias bibliográficas

      Visión general referenciasPub Med ID
      Atrial natriuretic factor: a hormone produced by the heart.
      de Bold, A J
      Science, 230: 767-70 (1985)  1985

      		2932797 2932797

      Productos y aplicaciones relacionados

      Related Products

      Número de referencia Descripción  
      AB5490 Anti-Atrial Natriuretic Peptide Antibody Precios y disponibilidad
      CBL66 Anti-Atrial Natriuretic Peptide Antibody, clone A6 Precios y disponibilidad
      MABC1032 Anti-Pro-Atrial Natriuretic Peptide Antibody, clone 11E3.9 Precios y disponibilidad

      Categorías

      Life Science Research > Antibodies and Assays > Primary Antibodies