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MABS1284-B Anti-Apolipoprotein(a) Antibody, clone LPA4 Antibody, Biotin Conjugate

Anti-Apolipoprotein(a), clone LPA4, Biotin Conjugate, Cat. No. MABS1284-B, is a mouse monoclonal antibody that detects Apolipoprotein (a)/Apo(a)/Lp(a) in human and non-human primates and has been tested for use in ELISA, Immunoprecipitation, and Western Blotting.

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Research Category: Signaling Gene Symbol: LPA UniProt Number: P08519
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MABS1284-B
100 μg  
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      Descripción

      Replacement Information

      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, NhPELISA, IP, WBMBiotinMonoclonal Antibody
      Description
      Catalogue NumberMABS1284-B
      DescriptionAnti-Apolipoprotein(a) Antibody, clone LPA4 Antibody, Biotin Conjugate
      Alternate Names
      • Apo(a)
      • Lp(a)
      Background InformationApolipoprotein(a) (UniProt P08519; also known as Apo(a), Lp(a)) is encoded by the LPA gene (Gene ID 4018) in human. Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It is synthesized with a signal peptide (aa 1-19) that is subsequently cleaved off. Lipoprotein (a)/Lp(a) is composed of Apo(a) covalently bound to apolipoprotein B-100/ApoB via a single disulfide bond on kringle (K)IV type 9 (KIV9) to a site near ApoB low density lipoprotein (LDL) receptor-binding site. Structurally, Apo (a) contains ten subtypes of KIV sequences, with the KIV2 subtype present in multiple identical repeats, followed by a KV sequence and an inactive protease domain. Elevated levels of Lp(a) are considered as a risk factor in the development of cardiovascular diseases and peripheral arterial disease. Lp(a) is a preferential lipoprotein carrier of oxidized phospholipids (OxPLs) and circulating levels of oxidized LDL are strongly associated with angiographically documented coronary artery disease. Apo(a) is known to be proteolytically cleaved. Apo(a) fragments accumulate in atherosclerotic lesions, where they may promote thrombogenesis.
      References
      Product Information
      FormatBiotin
      PresentationPurified mouse monoclonal antibody IgG1 in PBS with 1.5% BSA and 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Apolipoprotein(a), clone LPA4, Biotin Conjugate, Cat. No. MABS1284-B, is a mouse monoclonal antibody that detects Apolipoprotein (a)/Apo(a)/Lp(a) in human and non-human primates and has been tested for use in ELISA, Immunoprecipitation, and Western Blotting.
      Key Applications
      • ELISA
      • Immunoprecipitation
      • Western Blotting
      Application NotesELISA Analysis: A representative lot detected Apolipoprotein(a) in ELISA applications (Pedersen, T.X., et. al. (2010). J Lipid Res. 51(10):2967-75; Leibundgut, G., et. al. (2013). J Lipid Res. 54(10):2815-30).

      ELISA Analysis: 0.1 µg/mL from a representative lot detected Apolipoprotein(a) in Patient Lp(a) Plasma sample (Courtesy of Dr. Sotirios Tsimikas, M.D., University of California at San Diego, USA).

      Immunoprecipitation Analysis: A representative lot detected Apolipoprotein(a) in Immunoprecipitation applications (Tsimikas, S., et. al. (2004). Circulation. 109(25):3164-70).

      Western Blotting Analysis: A representative lot detected Apolipoprotein(a) in Western Blotting applications (Leibundgut, G., et. al. (2013). J Lipid Res. 54(10):2815-30).
      Biological Information
      ImmunogenHuman Lipoprotein a (Lp(a)).
      CloneLPA4
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone LPA4 detects Apolipoprotein(a) in human and non-human primates.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      • Non-human Primate
      Species Reactivity NoteHuman, Non-Human Primates.
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • LPA
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight501.32 kDa calculated for Apolipoprotein A
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceN/A
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      MABS1284-B 04054839396687