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ABT260 Anti-Amelogenin, X isoform/AMELX Antibody

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ABT260
100 µL  
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      Descripción

      Replacement Information

      Ofertas especiales

      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, PorcineWB, IHCRbSerumPolyclonal Antibody
      Description
      Catalogue NumberABT260
      DescriptionAnti-Amelogenin, X isoform/AMELX Antibody
      Alternate Names
      • Amelogenin, X isoform
      • Leucine-rich amelogenin peptide
      • LRAP
      Background InformationAmelogenin, X isoform/AMELX, also known as Leucine-rich Amelogenin peptide, or LRAP, and encoded by the gene AMELX/AMG/AMGX, is an important protein in the biomineralization of teeth. AMELX appears to regulate the formation of crystallites during the secretory stage of tooth enamel development. AMELX is a secreted extracellular matrix protein that has many isoforms. Interestingly mutations in the AMELX protein are associated with changes in enamel microstructure that are linked with severe dental disease, and the various isoforms of AMELX protein all aid in increasing enamel thickness of the developing tooth.
      References
      Product Information
      FormatSerum
      PresentationRabbit polyclonal serum with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Amelogenin, X isoform/AMELX Antibody is an antibody against Amelogenin for use in western blotting & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesWestern Blotting Analysis: A 1:1,000 dilution of this antibody detected Amelogenin, X isoform/AMELX using recombinant mouse Amelogenin179.

      Western Blotting Analysis: A representative lot from an independent laboratory detected Amelogenin, X isoform/AMELX in DESC spheres and cervical loop lysates (Chang, J. Y., et al. (2013). J Cell Biol. 288(40):28952-289561.).

      Immunohistochemistry Analysis: A representative lot from an independent laboratory detected Amelogenin, X isoform/AMELX in DESC spheres and cervical loops (Chang, J. Y., et al. (2013). J Cell Biol. 288(40):28952-289561.).

      Immunohistochemistry Analysis: A representative lot from an independent laboratory detected Amelogenin, X isoform/AMELX in normal ameloblasts in the wild type and the pseudostratified layer and amorphous matrix of the null mice (Rios, H., et al. (2005). Mol Cell. Biol. 25(24):11131-11144.).
      Biological Information
      ImmunogenRecombinant protein corresponding to mouse Amelogenin, X isoform/AMELX.
      HostRabbit
      Species Reactivity
      • Mouse
      • Porcine
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Amelx
      • Amel
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~23 kDa observed. At least 3 isoforms may be observed between 19-23 kDa in pig enamel acid extracts (Chang, J. Y., et al. (2013). J Cell Biol. 288(40):28952-289561.). Uncharacterized band(s) may be observed in some cell lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in pig enamel acid extract.

      Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Amelogenin, X isoform/AMELX in pig enamel acid extract.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      ABT260 04053252976872

      Documentation

      Anti-Amelogenin, X isoform/AMELX Antibody Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Anti-Amelogenin, X isoform/AMELX Antibody Certificados de análisis

      CargoNúmero de lote
      Anti-Amelogenin, X isoform/AMELX - Q2430179 Q2430179
      Anti-Amelogenin, X isoform/AMELX - 3267284 3267284
      Anti-Amelogenin, X isoform/AMELX - 3860854 3860854
      Anti-Amelogenin, X isoform/AMELX - 4037080 4037080
      Anti-Amelogenin, X isoform/AMELX - 4068637 4068637
      Anti-Amelogenin, X isoform/AMELX -2885161 2885161
      Anti-Amelogenin, X isoform/AMELX Polyclonal Antibody 2945577

      Referencias bibliográficas

      Visión general referenciasPub Med ID
      Fibroblast growth factor signaling is essential for self-renewal of dental epithelial stem cells.
      Chang, Julia Yu Fong, et al.
      J. Biol. Chem., 288: 28952-61 (2013)  2013

      Mostrar resumen
      23979135 23979135
      periostin null mice exhibit dwarfism, incisor enamel defects, and an early-onset periodontal disease-like phenotype.
      Rios, Hector, et al.
      Mol. Cell. Biol., 25: 11131-44 (2005)  2004

      Mostrar resumen
      16314533 16314533