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MABT153 Anti-Aggrecan Antibody (full length), clone 4D7.1

This Anti-Aggrecan Antibody (full length), clone 4D7.1 is validated for use in Western Blotting for the detection of Aggrecan (full length).

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Research Category: Cell Structure Research Sub-Category: ECM Proteins Gene Symbol: ACAN, AGC1, CSPG1, MSK16 UniProt Number: P16112
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MABT153
100 µg  
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      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABT153
      DescriptionAnti-Aggrecan Antibody (full length), clone 4D7.1
      Alternate Names
      • Aggrecan core protein
      • Cartilage-specific proteoglycan core protein
      • CSPCP
      • Chondroitin sulfate proteoglycan core protein 1
      • Chondroitin sulfate proteoglycan 1
      Background InformationAggrecan is an extracellular protein that is also known as Aggrecan core protein, Cartilage-specific proteoglycan core protein (CSPCP), Chondroitin sulfate proteoglycan core protein 1, and Chondroitin sulfate proteoglycan 1. Aggrecan is encoded by the gene ACAN/AGC1/CSPG1/MSK16. Aggrecan is a proteoglycan that is a major component of the extracellular matrix of cartilaginous tissues. The major function of Aggrecan is to resist compression in cartilage, thus providing protection for joint movement and against injury. Aggrecan binds various other ECM proteins via its large globular domains. Aggrecan can be cleaved into Aggrecan core protein 2, a C-terminal fragment component that decreases in cartilage as people age. Aggrecan is expressed in cartilage and is a massive (>2500 kDa) proteoglycan protein that has multiple isoforms. The appearance of Aggrecan fragments in the blood is a marker for various joint diseases.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Aggrecan Antibody (full length), clone 4D7.1 is validated for use in Western Blotting for the detection of Aggrecan (full length).
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human Aggrecan.
      Clone4D7.1
      Concentration1 mg/mL
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ACAN
      • AGC1
      • CSPG1
      • MSK16
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~270 kDa observed. The calculated molecular weight is 250 kDa. However, this protein is known to be highly glycosylated and may be observed at higher molecular weights.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human chondrocyte cell lysate.

      Western Blotting Analysis: 2 µg/mL of this antibody detected Aggrecan (full length) in 10 µg of human chondrocyte cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      MABT153 04053252975646

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      Categorías

      Life Science Research > Antibodies and Assays > Primary Antibodies