Millipore Sigma Vibrant Logo

MABT84 Anti-Aggrecan Antibody, clone 1-C-6

This Anti-Aggrecan Antibody, clone 1-C-6 is validated for use in IH, WB for the detection of Aggrecan.

Anti-Aggrecan Antibody, clone 1-C-6: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Research Category: Cell Structure Research Sub-Category: ECM Proteins Gene Symbol: Acan, Agc, Agc1 UniProt Number: P07897
View Products on Sigmaaldrich.com
MABT84
100 µg  
Recuperando precio...
No pudo obtenerse el precio
La cantidad mínima tiene que ser múltiplo de
Maximum Quantity is
Al finalizar el pedido Más información
Ahorró ()
 
—
Solicitar precio
—
Disponibilidad a confirmar Disponibilidad a confirmar
Ingrese cantidad 
Suspendido
Cantidades limitadas disponibles
Debe confirmarse disponibilidad
    El resto: se avisará
      El resto: se avisará
      Se avisará
      Póngase en contacto con el Servicio de Atención al Cliente
      Contact Customer Service

      Ofertas especiales

       

      Póngase en contacto con el Servicio de Atención al Cliente

      Descripción

      Replacement Information

      Ofertas especiales

      100% Performance Guaranteed

      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R, M, BIHC, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABT84
      DescriptionAnti-Aggrecan Antibody, clone 1-C-6
      Alternate Names
      • Aggrecan core protein
      • Cartilage-specific proteoglycan core protein
      • CSPCP
      Background InformationAggregating chondroitin sulfate proteoglycan or aggrecan, is one of the most studied proteoglycans. Many individual monomers of aggrecan bind to hyaluronic acid to form an aggregate, the monomer is known as aggrecan. The aggregates are comprised of up to 100 monomers attached to a single chain of hyaluronic acid. The high content of negatively charged polysaccharide chains contributes to the osmotic swelling of cartilage and in combination with intact collagen fibers results in articular cartilage resistance to compressive forces and high tensile strength. Aggrecan is abundant in articular cartilage and compromises 10% of its dry weight.
      References
      Product Information
      FormatPurified
      Control
      • Normal mouse cartilage and normal rat cartilage tissues
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Aggrecan Antibody, clone 1-C-6 is validated for use in IH, WB for the detection of Aggrecan.
      Key Applications
      • Immunohistochemistry
      • Western Blotting
      Application NotesWestern Blot Analysis: 1 µg/mL from a representative lot detected Aggrecan on 10 µg of A1D4 protein fraction from Bovine tissue.
      Biological Information
      ImmunogenReduced and alkylated Aggrecan isolated from Swarm Rat Chondrosarcoma
      Clone1-C-6
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Rat
      • Mouse
      • Bovine
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryAn extracellular matrix proteoglycan; cleaved by ADAMTS1 [RGD, Feb 2006].
      Gene Symbol
      • Acan
      • Agc
      • Agc1
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.

      SUBUNIT STRUCTURE: Interacts with FBLN1 and COMP (By similarity).

      SUBCELLULAR LOCATION: Secreted › extracellular space › extracellular matrix (By similarity).

      DOMAIN: Two globular domains, G1 and G2, comprise the N-terminus of the proteoglycan, while another globular region, G3, makes up the C-terminus. G1 contains Link domains and thus consists of three disulfide-bonded loop structures designated as the A, B, B' motifs. G2 is similar to G1. The keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3.

      PTM: Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides.

      SEQUENCE SIMILARITIES: Belongs to the aggrecan/versican proteoglycan family.

      Contains 1 C-type lectin domain.

      Contains 1 Ig-like V-type (immunoglobulin-like) domain.

      Contains 4 Link domains.

      Contains 1 Sushi (CCP/SCR) domain.
      Molecular WeightVarious
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in normal mouse cartilage and normal rat cartilage tissues.

      Immunohistochemistry Analysis: A 1:1,000 dilution of this antibody detected Aggrecan in normal mouse cartilage and normal rat cartilage tissues.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      MABT84 04053252633713

      Documentation

      Anti-Aggrecan Antibody, clone 1-C-6 Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Anti-Aggrecan Antibody, clone 1-C-6 Certificados de análisis

      CargoNúmero de lote
      Anti-Aggrecan, clone 1-C-6 - 2246809 2246809
      Anti-Aggrecan, clone 1-C-6 - 3184796 3184796
      Anti-Aggrecan, clone 1-C-6 - 3200631 3200631
      Anti-Aggrecan, clone 1-C-6 - 3695366 3695366
      Anti-Aggrecan, clone 1-C-6 - 3756228 3756228
      Anti-Aggrecan, clone 1-C-6 - 4061129 4061129
      Anti-Aggrecan, clone 1-C-6 - NRG1935584 NRG1935584
      Anti-Aggrecan, clone 1-C-6 -2545769 2545769
      Anti-Aggrecan, clone 1-C-6 -2567126 2567126
      Anti-Aggrecan, clone 1-C-6 -2605490 2605490
      Show more