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14-339M Akt2/PKBβ (δPH, S474D) Protein, active, 250 µg

Active, recombinant human PKBβ, residues 120-481, S474D, containing an N-terminal His6 tag, activated by PDK1. For use in Kinase Assays.

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14-339M
250 µg  Also available in 10 μg size (cat#14-339) and in bulk (cat# 14-339-K).
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      Descripción

      Replacement Information
      Description
      Catalogue Number14-339M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAkt2/PKBβ (δPH, S474D) Protein, active, 250 µg
      OverviewRecombinant human PKBβ, residues 120-481, S474D, containing an N-terminal His6 tag; activated by PDK1.
      References
      Product Information
      Quality LevelMQ300
      Applications
      ApplicationActive, recombinant human PKBβ, residues 120-481, S474D, containing an N-terminal His6 tag, activated by PDK1. For use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceExpressed by baculovirus in Sf21 insect cells.
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryThis gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins.
      Gene Symbol
      • AKT2
      • RAC-BETA
      • PRKBB
      • PKBBETA
      • RAC-PK-beta
      Protein TargetAkt2/PKBβ
      Purification MethodNi2+/NTA-agarose & heparin-Sepharose™ chromatography
      Target Sub-FamilyAGC
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P31751 # General protein kinase capable of phosphorylating several known proteins.
      SIZE: 481 amino acids; 55769 Da
      TISSUE SPECIFICITY: In all human cell types so far analyzed.
      DISEASE:SwissProt: P31751 # Alterations of AKT2 may contribute to the pathogenesis of ovarian carcinomas.
      SIMILARITY: SwissProt: P31751 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 PH domain. & Contains 1 protein kinase domain.
      Molecular Weight42.8kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by phosphorylation of Crosstide
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions1 year at -70°C
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-339) and in bulk (cat# 14-339-K).
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      14-339M 04053252332890

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      Alternative Packsize

      Número de referencia Descripción  
      14-339 Akt2/PKBβ (δPH, S474D) Protein, active, 10 µg Precios y disponibilidad

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      Categorías

      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases