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124013 Akt Inhibitor VI, Akt-in - Calbiochem

The Akt Inhibitor VI, Akt-in controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Akt Inhibitor VI, Akt-in - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: TCL1₁₀₋₂₄, H-AVTDHPDRLWAWEKF-OH

Primary Target: Akt
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical Formula
      C₈₈H₁₂₃N₂₃O₂₃
      Description
      OverviewA reversible 15-mer peptide derived from proto-oncogene TCL1 (amino acids 10-24) that acts as a specific inhibitor of Akt. Shown to bind to Akt-PH domain (Kd ~18 µM) and interfere with the Akt-phosphoinositide interaction, thus hindering membrane translocation from the cytosol and downstream biological responses.
      Catalogue Number124013
      Brand Family Calbiochem®
      SynonymsTCL1₁₀₋₂₄, H-AVTDHPDRLWAWEKF-OH
      References
      ReferencesHiromura, M., et al. 2004. J. Biol. Chem. 279, 53407.
      Product Information
      ATP CompetitiveN
      FormWhite lyophilized solid
      FormulationSupplied as an acetate salt.
      Hill FormulaC₈₈H₁₂₃N₂₃O₂₃
      Chemical formulaC₈₈H₁₂₃N₂₃O₂₃
      Hygroscopic Hygroscopic
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetAkt
      Primary Target IC<sub>50</sub>Kd ~18 µM in binding to Akt-PH domain
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceH-Ala-Val-Thr-Asp-His-Pro-Asp-Arg-Leu-Trp-Ala-Trp-Glu-Lys-Phe-OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      124013 0

      Documentation

      Akt Inhibitor VI, Akt-in - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Akt Inhibitor VI, Akt-in - Calbiochem Certificados de análisis

      CargoNúmero de lote
      124013

      Referencias bibliográficas

      Visión general referencias
      Hiromura, M., et al. 2004. J. Biol. Chem. 279, 53407.

      Folleto

      Cargo
      Akt
      Biologics 31.1
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-November-2009 RFH
      SynonymsTCL1₁₀₋₂₄, H-AVTDHPDRLWAWEKF-OH
      DescriptionA reversible 15-mer peptide derived from the amino acids 10-24 of the proto-oncogene TCL1 (TCL10-24) and acts as a specific inhibitor of Akt. Shown to bind to the Akt-PH domain (Kd ~18 µM) and interfere with the Akt-phosphoinositide interaction. This peptide, when made cell-permeable (Cat. No. 124014), has been shown to hinder Akt membrane translocation from the cytosol and subsequent downstream biological responses.
      FormWhite lyophilized solid
      FormulationSupplied as an acetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₈₈H₁₂₃N₂₃O₂₃
      Peptide SequenceH-Ala-Val-Thr-Asp-His-Pro-Asp-Arg-Leu-Trp-Ala-Trp-Glu-Lys-Phe-OH
      Purity≥95% by HPLC
      SolubilityH₂O (1 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesHiromura, M., et al. 2004. J. Biol. Chem. 279, 53407.