Millipore Sigma Vibrant Logo

124008 Akt Inhibitor II - Calbiochem

Akt Inhibitor II, CAS 701976-54-7, is a cell permeable, reversible, and substrate competitive phosphatidylinositol analog that inhibits the activation of Akt & downstream substrates.

Akt Inhibitor II - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: SH-5

Primary Target: Akt
View Products on Sigmaaldrich.com
124008
Ver precios y disponibilidad

Descripción

Tabla espec. clave

Empirical Formula
C₂₉H₅₉O₁₀P

Precios y disponibilidad

Número de referencia DisponiblidadEmbalaje Cant./Env. Precio Cantidad
124008-1MG
—
Disponibilidad a confirmar Disponibilidad a confirmar
Ingrese cantidad 
Suspendido
Cantidades limitadas disponibles
Debe confirmarse disponibilidad
    El resto: se avisará
      El resto: se avisará
      Se avisará
      Póngase en contacto con el Servicio de Atención al Cliente
      Contact Customer Service

      		 Ampolla de plást. 1 mg
      No pudo obtenerse el precio
      La cantidad mínima tiene que ser múltiplo de
      Maximum Quantity is
      Al finalizar el pedido Más información
      Ahorró ()
       
      —
      Solicitar precio
      		 —
      Añadir a favoritos
      Description
      OverviewA cell permeable, reversible, and substrate competitive phosphatidylinositol analog that inhibits the activation of Akt and select downstream substrates without decreasing phosphorylation of PDK-1 or other kinases downstream of Ras, such as MAPK. Also acts as a potent inducer of apoptosis and selectively kills a variety of cancer cell lines that contain high levels of active Akt. When used at a concentration of 10 µM, it is reported to activate p38α/SAPK2α MAP kinase. At 10 µM it will also inhibit ~50% of PKA activity.
      Catalogue Number124008
      Brand Family Calbiochem®
      SynonymsSH-5
      References
      ReferencesGills, J.J., et al. 2007. J. Biol. Chem. in press.
      Kozikowski, A.P., et al. 2003. J. Am. Chem. Soc.125, 1144.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₉H₅₉O₁₀P
      Chemical formulaC₂₉H₅₉O₁₀P
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationAkt Inhibitor II, CAS 701976-54-7, is a cell permeable, reversible, and substrate competitive phosphatidylinositol analog that inhibits the activation of Akt & downstream substrates.
      Biological Information
      Primary TargetAkt
      Purity≥98% by NMR
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Número de referencia GTIN
      124008-1MG 04055977206333