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102555 Abl Protein Tyrosine Kinase, Recombinant, E. coli

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: v-Abl

102555
  
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      Descripción

      Replacement Information
      Description
      Overview

      This product has been discontinued.



      Recombinant, truncated form of the v-Abl protein tyrosine kinase that contains the minimum region required for both kinase activity and fibroblast transformation expressed in E. coli. The catalytic domain of v-Abl is identical to that of c-Abl. Induces resistance to anti-cancer drugs by suppressing apoptosis, probably by upregulating Bcl-xL protein.
      Catalogue Number102555
      Brand Family Calbiochem®
      Synonymsv-Abl
      References
      ReferencesChen, Q., et al. 1997. Oncogene 15, 2249.
      Chapman, R.S., et al. 1995. Mol. Pharmacol. 48, 334.
      Evans, C.A., et al. 1995. J. Cell Sci. 108, 2591.
      Foulkes, J.G., et al. 1985. J. Biol. Chem. 260, 8070.
      Product Information
      Activity≥100,000 units/ml
      Unit of DefinitionOne unit is defined as the amount of enzyme that will catalyze the transfer of 1.0 pmol phosphate to EAIYAAPFAKKK per min at 30°C, pH 7.5.
      FormLiquid
      FormulationIn 100 mM NaCl, 50 mM HEPES, 1 mM DTT, 100 µM EDTA, 50% glycerol, 0.01% BRIJ® 35 Detergent, pH 7.5.
      Quality LevelMQ100
      Applications
      Biological Information
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      102555 0

      Documentation

      Abl Protein Tyrosine Kinase, Recombinant, E. coli Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Abl Protein Tyrosine Kinase, Recombinant, E. coli Certificados de análisis

      CargoNúmero de lote
      102555

      Referencias bibliográficas

      Visión general referencias
      Chen, Q., et al. 1997. Oncogene 15, 2249.
      Chapman, R.S., et al. 1995. Mol. Pharmacol. 48, 334.
      Evans, C.A., et al. 1995. J. Cell Sci. 108, 2591.
      Foulkes, J.G., et al. 1985. J. Biol. Chem. 260, 8070.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-June-2009 JSW
      Synonymsv-Abl
      DescriptionRecombinant, truncated form of the v-Abl protein tyrosine kinase that contains the minimum region required for both kinase activity and fibroblast transformation expressed in E. coli. The catalytic domain of v-abl is identical to that of c-abl. Induces resistance to anti-cancer drugs by suppressing apoptosis. Also involved in the upregulation of Bcl-xL protein.
      FormLiquid
      FormulationIn 100 mM NaCl, 50 mM HEPES, 1 mM DTT, 100 µM EDTA, 50% glycerol, 0.01% BRIJ® 35 Detergent, pH 7.5.
      Concentration Label Please refer to vial label for lot-specific concentration
      Recommended reaction conditions1x kinase buffer: 50 mM Tris-HCl, 10 mM MgCl2, 100 µM EDTA, 1 mM DTT, 100 µM ATP (γ-ATP to 100 µCi/µmol), 0.015% BRIJ® 35 detergent, and 100 µg/ml BSA. Incubate at 30°C. Note: optimal reaction conditions need to be established empirically for each substrate.
      Activity≥100,000 units/ml
      Unit definitionOne unit is defined as the amount of enzyme that will catalyze the transfer of 1.0 pmol phosphate to EAIYAAPFAKKK per min at 30°C, pH 7.5.
      Storage Avoid freeze/thaw
      ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Toxicity Standard Handling
      ReferencesChen, Q., et al. 1997. Oncogene 15, 2249.
      Chapman, R.S., et al. 1995. Mol. Pharmacol. 48, 334.
      Evans, C.A., et al. 1995. J. Cell Sci. 108, 2591.
      Foulkes, J.G., et al. 1985. J. Biol. Chem. 260, 8070.