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14-756M ACK1 Protein, active, 250 µg

Active, N-terminal GST-tagged recombinant, human ACK1, residues 1-389. For use in Kinase Assays.

ACK1 Protein, active, 250 µg: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
14-756M
250 µg  Also available in 10 μg size (cat#14-756) and in bulk (cat# 14-756-K).
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      Descripción

      Replacement Information
      Description
      Catalogue Number14-756M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionACK1 Protein, active, 250 µg
      OverviewN-terminal GST-tagged recombinant, human ACK1, residues 1-389.
      Alternate Names
      • Activated CDC42 kinase 1
      • ACK-1
      • Tyrosine kinase non-receptor protein 2
      References
      Product Information
      Quality LevelMQ300
      Applications
      ApplicationActive, N-terminal GST-tagged recombinant, human ACK1, residues 1-389. For use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceExpressed by baculovirus in Sf21 insect cells.
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.
      Gene Symbol
      • TNK2
      • FLJ44758
      • ACK1
      • p21cdc42Hs
      • ACK
      • ACK-1
      • FLJ45547
      Protein TargetACK1
      Purification MethodGlutathione-agarose
      Target Sub-FamilyTK
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q07912 # Downstream effector of CDC42 which mediates CDC42- dependent cell migration via phosphorylation of BCAR1. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR. Participates in clathrin-mediated endocytosis. May be involved both in adult synaptic function and plasticity and in brain development.
      COFACTOR: Magnesium.
      SIZE: 1036 amino acids; 114327 Da
      SUBUNIT: Interacts with CDC42. Interacts with activated CSPG4.
      SUBCELLULAR LOCATION: Cell membrane (By similarity).
      SIMILARITY: SwissProt: Q07912 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. & Contains 1 CRIB domain. & Contains 1 protein kinase domain. & Contains 1 SH3 domain.
      Molecular Weight71.5 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions-70°C from date of shipment.
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-756) and in bulk (cat# 14-756-K).
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      14-756M 04053252478895

      Documentation

      ACK1 Protein, active, 250 µg Certificados de análisis

      CargoNúmero de lote
      ACK1, active - D13HP014NB D13HP014NB