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171588 Aβ₄₂ Fibrillogenesis Inhibitor III - Calbiochem

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      Descripción

      Tabla espec. clave

      Empirical Formula
      C₃₅H₄₆N₆O₈
      Description
      Overview

      This product has been discontinued.



      A modified analog of Aβ42 Fibrillogenesis Inhibitor I (Cat. No. 171586) that crosses the blood-brain barrier and acts as a β-sheet breaker. Reported to increase neuronal survival and reduce brain inflammation in a transgenic mouse model of Alzheimer’s disease, probably due to a reduction in Aβ deposits. Displays greater stability against proteolytic degradation (t1/2 > 24 hours in human plasma and cerebrospinal fluid; ~ 37 minutes in blood).

      Catalogue Number171588
      Brand Family Calbiochem®
      SynonymsAmyloid β₄₂ Fibrillogenesis Inhibitor III, iAβ5p, Ac-LPFFD-NH₂
      References
      ReferencesPermanne, B., et al. 2002. FASEB J. 16, 860.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₃₅H₄₆N₆O₈
      Chemical formulaC₃₅H₄₆N₆O₈
      ReversibleN
      Quality LevelMQ100
      Biological Information
      Primary TargetReduction in Aβ deposits
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceAc-Leu-Pro-Phe-Phe-Asp-NH₂
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions in DMSO are stable for up to 6 months at -20°C. Stock solutions in H₂O are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Número de referencia GTIN
      171588 0