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499610 (5Z)-7-Oxozeaenol, Curvularia sp. - CAS 66018-38-0 - Calbiochem

(5Z)-7-Oxozeaenol, CAS 66018-38-0, is a cell-permeable, highly potent, selective, irreversible, and ATP-competitive inhibitor of MAPKKK TAK1 activity (IC₅₀ = 8 nM).

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: TAK1 Inhibitor

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499610
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Replacement Information

Tabla espec. clave

CAS #Empirical Formula
66018-38-0C₁₉H₂₂O₇

Precios y disponibilidad

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      Description
      OverviewA naturally isolated cell-permeable fungal resorcylic lactone that acts as a selective and highly potent inhibitor against the MAPKKK TAK1 activity (IC50 = 8 nM) in an ATP-competitive and irreversible manner, while inhibiting MEK1 (IC50 = 411 nM) and three other MAPKKKs (IC50 ≥268 nM against MEKK1, ASK1, and MEKK4) only at much higher concentrations. Shown to inhibit IL-1-induced/TAK1-mediated, but not H2O2-induced/TAK1-independent, JNK and p38 phosphorylation in 293 cells. (5Z)-Zeaenol, Curvularia sp. (Cat. No. 499609) may serve as a negative control.
      Catalogue Number499610
      Brand Family Calbiochem®
      SynonymsTAK1 Inhibitor
      References
      ReferencesWindheim, M., et al. 2007. Biochem. J. 404, 179.
      Choo, M.K., et al. 2006. Mol. Cancer Ther. 5, 2970.
      Safwat, N., et al. 2005. Endocrinology 146, 4814.
      Ninomiya-Tsuji, J., et al. 2003. J. Biol. Chem. 278, 18485.
      Rawlins, P., et al. 1999. Int. J. Immunopharmacol. 21, 799.
      Product Information
      CAS number66018-38-0
      FormWhite solid
      Hill FormulaC₁₉H₂₂O₇
      Chemical formulaC₁₉H₂₂O₇
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      S PhraseS: 22-24/25-36/37/39

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable protective clothing, gloves and eye/face protection.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      499610-1MG 04055977199277

      Documentation

      (5Z)-7-Oxozeaenol, Curvularia sp. - CAS 66018-38-0 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      (5Z)-7-Oxozeaenol, Curvularia sp. - CAS 66018-38-0 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      499610

      Referencias bibliográficas

      Visión general referencias
      Windheim, M., et al. 2007. Biochem. J. 404, 179.
      Choo, M.K., et al. 2006. Mol. Cancer Ther. 5, 2970.
      Safwat, N., et al. 2005. Endocrinology 146, 4814.
      Ninomiya-Tsuji, J., et al. 2003. J. Biol. Chem. 278, 18485.
      Rawlins, P., et al. 1999. Int. J. Immunopharmacol. 21, 799.

      Folleto

      Cargo
      Pathways and Biomarkers of Toll-like Receptor (TLR) Signaling
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-December-2018 JSW
      SynonymsTAK1 Inhibitor
      DescriptionA naturally isolated cell-permeable fungal resorcylic lactone that acts as a selective and highly potent inhibitor against the MAPKKK TAK1 activity (IC50 = 8 nM) in an ATP-competitive and irreversible manner, while inhibiting MEK1 (IC50 = 411 nM) and three other MAPKKKs (IC50 ≥268 nM against MEKK1, ASK1, and MEKK4) only at much higher concentrations. Shown to inhibit IL-1-induced/TAK1-mediated, but not H2O2-induced/TAK1-independent, JNK and p38 phosphorylation in 293 cells. (5Z)-Zeaenol, Curvularia sp.(Cat. No. 499609) may serve as a negative control.
      FormWhite solid
      CAS number66018-38-0
      Chemical formulaC₁₉H₂₂O₇
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesWindheim, M., et al. 2007. Biochem. J. 404, 179.
      Choo, M.K., et al. 2006. Mol. Cancer Ther. 5, 2970.
      Safwat, N., et al. 2005. Endocrinology 146, 4814.
      Ninomiya-Tsuji, J., et al. 2003. J. Biol. Chem. 278, 18485.
      Rawlins, P., et al. 1999. Int. J. Immunopharmacol. 21, 799.