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407900 5-Iodotubercidin

5-Iodotubercidin: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: 4-Amino-5-iodo-7-(β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine, ITU

407900
  
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      Descripción

      Description
      Overview

      This product has been discontinued.





      A cell-permeable, potent and competitive inhibitor of the MAP kinase ERK2 (Ki = 530 nM). Also inhibits adenosine kinase (Ki = 30 nM), serine/threonine kinases such as casein kinase I and PKA, and the insulin receptor kinase fragment (IC50 = 0.4-28 µM).
      Catalogue Number407900
      Brand Family Calbiochem®
      Synonyms4-Amino-5-iodo-7-(β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine, ITU
      References
      ReferencesFox, T., et al. 1998. Protein Science 7, 2249.
      Parkinson, F.E., et al. 1996. J. Pharmacol. Exp. Ther. 277, 1397.
      Massillon, D., et al. 1994. Biochem. J. 299, 123.
      Cottam, H.B., et al. 1993. J. Med. Chem. 36, 3424.
      Newby, A.C., et al. 1993. Biochem. J. 214, 317.
      Product Information
      CAS number24386-93-4
      FormTan solid
      Hill FormulaC₁₁H₁₃IN₄O₄
      Chemical formulaC₁₁H₁₃IN₄O₄
      Structure formula ImageStructure formula Image
      Biological Information
      Primary TargetERK2
      Primary Target K<sub>i</sub>530 nM
      Secondary targetadenosine kinase (IC₅₀ = 30 nM)
      Purity≥90% by HPLC
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Número de referencia GTIN
      407900 0