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  • Histones and Histone Modifications | Life Science Research | Merck

    Histone modifications regulate DNA transcription, repair, recombination, and replication, and can alter local chromatin architecture. Understanding histone modifications is key to uncovering epigenetic mechanisms of gene regulation. Merck grasps the complexity of this research and provides a growing line of kits, antibodies, and assays for studying histones and their modifications. Merck offers over 600 validated antibodies, recombinant proteins, and kits to analyze histone and histone-variant phosphorylation, methylation, acetylation, ubiquitination, and citrullination-the most widely studied histone modifications in epigenetics today.

  • Chromatin Associated Proteins | Life Science Research | Merck

    Chromatin is a complex molecule that can be found in either an open decondensed or active state (euchromatin) or in a tightly compacted inactive state (heterochromatin). Merck also offers a wide selection of ChIP-qualified antibodies against modified and unmodified histones, transcription factors, chromatin modifying proteins and other key chromatin associated proteins.

  • Cleavage Enzymes | Life Science Research | Merck

    Cleavage enzymes were found to cut DNA at specific sites, creating unique, gene-size fragments that could be fused together in the laboratory. Learn more about our best selling products designed for highly specific cleavage of fusion proteins followed by removal of enterokinase, factor Xa, HRV 3C protease and thrombin.

  • Chromatin | Life Science Research | Merck

    Chromatin is the complex of genomic DNA and associated proteins in the nucleus. It allows cells to package their DNA, provides a scaffold for cell division, and enables control of gene expression.

  • DNA Methylation | Life Science Research | Merck

    DNA methylation is involved in the regulation of many cellular processes, including chromosome stability, chromatin structure, X chromosome inactivation, embryonic development, and transcription. DNA methylation occurs mainly at the 5' position of cytosine bases and is mediated by enzymes called DNA methyltransferases (DNMT). Regions of methylated DNA can be bound by a variety of methylated DNA binding proteins (MBD).