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  • iPS cell-derived cardiogenicity is hindered by sustained integration of reprogramming transgenes. 25077947

    Nuclear reprogramming inculcates pluripotent capacity by which de novo tissue differentiation is enabled. Yet, introduction of ectopic reprogramming factors may desynchronize natural developmental schedules. This study aims to evaluate the effect of imposed transgene load on the cardiogenic competency of induced pluripotent stem...
    Document Type:
    Reference
    Product Catalog Number:
    AB1728
    Product Catalog Name:
    Anti-Connexin 43 Antibody, CT, cytosolic
  • iPS programmed without c-MYC yield proficient cardiogenesis for functional heart chimerism. 19696409

    RATIONALE: Induced pluripotent stem cells (iPS) allow derivation of pluripotent progenitors from somatic sources. Originally, iPS were induced by a stemness-related gene set that included the c-MYC oncogene. OBJECTIVE: Here, we determined from embryo to adult the cardiogenic proficiency of iPS programmed without c-MYC, a cardiog...
    Document Type:
    Reference
    Product Catalog Number:
    MAB4301
    Product Catalog Name:
    Anti-Stage-Specific Embryonic Antigen-1 Antibody, clone MC-480
  • Generation of iPS cells using defined factors linked via the self-cleaving 2A sequences in a single open reading frame. 19238173

    Generation of induced pluripotent stem (iPS) cells from somatic cells has been achieved successfully by simultaneous viral transduction of defined reprogramming transcription factors (TFs). However, the process requires multiple viral vectors for gene delivery. As a result, generated iPS cells harbor numerous viral integration s...
    Document Type:
    Reference
    Product Catalog Number:
    CBL171
    Product Catalog Name:
    Anti-Actin Antibody, smooth muscle, clone ASM-1
  • Efficient iPS cell production with the MyoD transactivation domain in serum-free culture. 22479546

    A major difficulty of producing induced pluripotent stem cells (iPSCs) has been the low efficiency of reprogramming differentiated cells into pluripotent cells. We previously showed that 5% of mouse embryonic fibroblasts (MEFs) were reprogrammed into iPSCs when they were transduced with a fusion gene composed of Oct4 and the tra...
    Document Type:
    Reference
    Product Catalog Number:
    SCR004
    Product Catalog Name:
    Alkaline Phosphatase Detection Kit
  • Genes inducing iPS phenotype play a role in hepatocyte survival and proliferation in vitro and liver regeneration in vivo. 21739467

    Reprogramming factors have been used to induce pluripotent stem cells as an alternative to somatic cell nuclear transfer technology in studies targeting disease models and regenerative medicine. The neuronal repressor RE-1 silencing transcription factor (REST) maintains self-renewal and pluripotency in mouse embryonic stem cells...
    Document Type:
    Reference
    Product Catalog Number:
    07-579
    Product Catalog Name:
    Anti-REST Antibody