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677181 Vincristine Sulfate, Apocynaceae sp. - CAS 2068-78-2 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
2068-78-2C₄₆H₅₆N₄O₁₀ · H₂SO₄

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677181-10MG
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      Description
      OverviewIndole alkaloid that binds to tubulin, inhibiting formation of microtubules. Depolymerizes microtubules. Induces increase in micronuclei and delays cell cycle progression. Anti-neoplastic agent. Induces apoptosis in human lymphoma cells by disrupting microtubules.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number677181
      Brand Family Calbiochem®
      References
      ReferencesChan, M.W., et al. 1998. Cancer Biochem. Biophys. 16, 347.
      Hanauske, A.R., et al. 1994. Eur. J. Cancer 30A, 1688.
      Takano, Y., et al. 1993. Pathol. Res. Pract. 189, 187.
      Product Information
      CAS number2068-78-2
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₄₆H₅₆N₄O₁₀ · H₂SO₄
      Chemical formulaC₄₆H₅₆N₄O₁₀ · H₂SO₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetTubulin
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableN
      Safety Information according to GHS
      RTECSOH6340000
      Safety Information
      R PhraseR: 36/37/38-60-61

      Irritating to eyes, respiratory system and skin.
      May impair fertility.
      May cause harm to the unborn child.
      S PhraseS: 22-26-36/37/39-45

      Do not breathe dust.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 1 month at 4°C.
      Global Trade Item Number
      Catalogue Number GTIN
      677181-10MG 04055977260601