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676499 VEGFR 2/3 Kinase Inhibitor

VEGFR 2/3 Kinase Inhibitor MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-(Indole-3-yl)-4-(3,4,5-trimethoxyphenyl)-1H-pyrrole-2,5-dione, Vascular Endothelial Growth Factor Receptor 2/3 Kinase Inhibitor, VEGFR Tyrosine Kinase Inhibitor XXII, VEGFR2 Kinase Inhibitor XIX, VEGFR3 Kinase Inhibitor IV

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      Overview

      Replacement Information
      Description
      Overview

      This product has been discontinued.

      Please refer to our complete listing of receptor tyrosine kinase inhibitors for possible alternatives. Please read the alternative product documentation carefully and contact technical service if you need additional information.





      A cell-permeable 2,3-diarylmaleimide compound that acts as a potent and ATP-competitive inhibitor of VEGFR-2 and -3 (IC50 = 2.5 nM and 5 nM, respectively) with >100-fold selectivity over 25 other commonly studied kinases. Exhibits excellent in vivo anti-angiogenic efficacy in chick embryo assay (81.7% inhibition of vessel area at the vasculosa site with agarose pellets containing 150 µg inhibitor).
      Catalogue Number676499
      Brand Family Calbiochem®
      Synonyms3-(Indole-3-yl)-4-(3,4,5-trimethoxyphenyl)-1H-pyrrole-2,5-dione, Vascular Endothelial Growth Factor Receptor 2/3 Kinase Inhibitor, VEGFR Tyrosine Kinase Inhibitor XXII, VEGFR2 Kinase Inhibitor XIX, VEGFR3 Kinase Inhibitor IV
      References
      ReferencesPeifer, C., et al. 2006. J. Med. Chem. 49, 7549. Peifer, C., et al. 2006. J. Med. Chem. 49, 1271.
      Product Information
      FormYellowish orange solid
      Hill FormulaC₂₁H₁₈N₂O₅
      Chemical formulaC₂₁H₁₈N₂O₅
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      676499 0

      Documentation

      VEGFR 2/3 Kinase Inhibitor Certificates of Analysis

      TitleLot Number
      676499

      References

      Reference overview
      Peifer, C., et al. 2006. J. Med. Chem. 49, 7549. Peifer, C., et al. 2006. J. Med. Chem. 49, 1271.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-August-2007 RFH
      Synonyms3-(Indole-3-yl)-4-(3,4,5-trimethoxyphenyl)-1H-pyrrole-2,5-dione, Vascular Endothelial Growth Factor Receptor 2/3 Kinase Inhibitor, VEGFR Tyrosine Kinase Inhibitor XXII, VEGFR2 Kinase Inhibitor XIX, VEGFR3 Kinase Inhibitor IV
      DescriptionA cell-permeable 2,3-diarylmaleimide compound that acts as a potent and ATP-competitive inhibitor of VEGFR-2 and -3 (IC50 = 2.5 nM and 5 nM, respectively) with >100-fold selectivity over 25 other commonly studied kinases. Exhibits excellent in vivo anti-angiogenic efficacy in chick embryo assay (81.7% inhibition of vessel area at the vasculosa site with agarose pellets containing 150 µg inhibitor).
      FormYellowish orange solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₁H₁₈N₂O₅
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (300 mg/ml) or Ethanol (1 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Irritant
      ReferencesPeifer, C., et al. 2006. J. Med. Chem. 49, 7549. Peifer, C., et al. 2006. J. Med. Chem. 49, 1271.