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SCC072 UM-SCC-104 HPV-16 Positive Squamous Carcinoma Cell Line

UM-SCC-104 is a unique head and neck squamous carcinoma (HNSCC) cell line derived from a 56-year old male with a recurrent oral cavity tumor naturally infected with high-risk human papillomavirus (HPV-16).

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Key Applications: Cell Culture
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SCC072
≥1X10⁶ cells/vial   
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      Overview

      Replacement Information

      Special Offers

      Explore additional UM-SCC cell lines:
      UM-SCC-1 Squamous Carcinoma Cell Line (Catalogue Number SCC070)
      UM-SCC-47 Squamous Carcinoma Cell Line (Catalogue Number SCC071)

      Key Spec Table

      Key Applications
      CULT
      Description
      Catalogue NumberSCC072
      DescriptionUM-SCC-104 HPV-16 Positive Squamous Carcinoma Cell Line
      Alternate Names
      • University Michigan Squamous Cell Carcinoma
      • UMSCC104
      • H&N squamous cell carcinoma cell line
      • Head and neck squamous cell carcinoma cell line
      • HNSCC
      Background InformationAll UM-SCC cell lines were derived in the lab of Dr. Thomas Carey at the University of Michigan and are exclusively distributed by Merck KGaA. Access to UM-SCC cells is limited solely to those officers, employees and students of PURCHASER’s institution who need access to perform research. PURCHASER may not distribute UM-SCC cells or derivatives to third parties. PURCHASER shall comply with all applicable laws in its use and handling of the Product and shall keep it under reasonable safe and secure conditions to prevent unauthorized use or access.

      THIS PRODUCT IS ONLY AVAILABLE FOR SALE TO ACADEMIC INSTITUTIONS OR NOT-FOR-PROFIT ENTITIES FOR USE UNDER THIS LIMITED USE LABEL LICENSE. FOR INFORMATION ON COMMERCIAL LICENSING OF UM-SCC CELLS, INCLUDING LICENSING TO COMMERCIAL ENTITIES, PLEASE CONTACT: licensing@emdmillipore.com

      Head and neck squamous-cell carcinoma (HNSCC) is the 6th most common type of cancer world-wide. The cancer may occur in the lip, oral cavity, nasal cavity, paranasal sinuses, salivary glands, pharynx and larynx. Risk factors include smoking, alcohol consumption, betel nut chewing, wood dust exposures and human papilloma virus (HPV) infections. Approximately 15% of HNSCC contain genomic DNA from HPV. In particular, HPV-16 occurs in 90-95% of all HPV-positive HNSCC cases. In oral and pharynx cancer, HPV DNA is found in the tonsils in 45-67% of the cases. HPV DNA is found in 13-25% of the cases in the hypopharynx, 12-18% in the oral cavity and 3-7% in the larynx.

      UM-SCC-104 is a unique head and neck squamous carcinoma cell line derived from a 56-year old male with a recurrent oral cavity tumor naturally infected with high-risk human papillomavirus (HPV-16). The patient had a history of moderate consumption of alcohol and smoking (20 pack/year). UM-SCC-104 contains a small population of ALDH+ cancer stem cells. The tumor from which the cell line was derived failed to respond to initial chemoradiation therapy and thus UM-SCC-104 is a useful model for preclinical studies of aggressive non-responsive tumors and may be used for studying the interplay between viral and carcinogen-related pathways in tumor progression.

      UM-SCC-104 was established at the University of Michigan with written informed consent obtained from the patient and with the approval of the study by the Medical School Institutional Review Board.

      Reference:
      1) Carey, T., et al. (2012) Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell lines. Head Neck. 2010 April; 32(4): 417–426.
      References
      Product Information
      Components
      • 1) ≥1X106 viable UM-SCC-104 Squamous Carcinoma Cells: (Catalog No. SCC072). Store in liquid nitrogen.
      Quality LevelMQ100
      Applications
      ApplicationUM-SCC-104 is a unique head and neck squamous carcinoma (HNSCC) cell line derived from a 56-year old male with a recurrent oral cavity tumor naturally infected with high-risk human papillomavirus (HPV-16).
      Key Applications
      • Cell Culture
      Application NotesThis product is available for sale to academic institutions or not-for-profit entities for research use. For information on commercial licensing please contact licensing@emdmillipore.com.
      Biological Information
      Cell Line Type
      • Cancer Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assurance• Each vial contains ≥ 1X10^6 viable cells.
      • Cells are tested by PCR and are positive for HPV-16 and negative for Hepatitis A, B, C and HIV-1 & 2 viruses.
      • Cells are negative for mycoplasma contamination.
      • Each lot of cells are genotyped by STR analysis to verify the unique identity of the cell line.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsUM-SCC-104 cells should be stored in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
      Packaging Information
      Material Size≥1X10⁶ cells/vial
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      SCC072 04055977179606

      Related Products & Applications

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      Categories

      Life Science Research > Cell Culture and Systems > Cell Lines