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654380 Tunicamycin, Streptomyces lysosuperficus - CAS 11089-65-9 - Calbiochem

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654380
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Overview

Key Spec Table

CAS #Empirical Formula
11089-65-9C₃₉H₆₄N₄O₁₆

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654380-10MG
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      		 Glass bottle 10 mg
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      654380-50MG
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          Description
          OverviewA nucleoside antibiotic that inhibits N-linked glycosylation and blocks the formation of N-glycosidic protein-carbohydrate linkages. Active in vitro against Gram-positive bacteria, yeasts, fungi, and viruses. Inhibits the expression of functional thrombin receptors on human T-lymphoblastoid cells. Also inhibits thrombin-induced Ca2+ mobilization in cells. Also available as a 25 mM solution in DMSO (Cat. No. 504570).
          Catalogue Number654380
          Brand Family Calbiochem®
          References
          ReferencesTordai, A., et al. 1995. Biochem. Biophys. Res. Commun. 206, 857.
          Price, B.D., et al. 1992. J. Cell Physiol. 152, 545.
          Product Information
          CAS number11089-65-9
          FormWhite to off-white solid
          Hill FormulaC₃₉H₆₄N₄O₁₆
          Chemical formulaC₃₉H₆₄N₄O₁₆
          ReconstitutionAqueous solutions can be prepared from stock solutions in DMSO by diluting with H₂O at pH 8.0 to 10.0 or with appropriate buffers at pH >7.0 (preferably >8.0).
          Structure formula ImageStructure formula Image
          Quality LevelMQ200
          Biological Information
          Primary TargetN-linked glycosylation
          Secondary targetthrombin-induced Ca2+ mobilization in cells
          Purity≥98% by HPLC (A+B+C+D)
          Safety Information according to GHS
          RTECSYO7980200
          Safety Information
          R PhraseR: 26/27/28-60-61

          Very toxic by inhalation, in contact with skin and if swallowed.
          May impair fertility.
          May cause harm to the unborn child.
          S PhraseS: 22-36/37/39-45

          Do not breathe dust.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Highly Toxic & Carcinogenic / Teratogenic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +15°C to +30°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
          Global Trade Item Number
          Catalogue Number GTIN
          654380-10MG 04055977184686
          654380-50MG 04055977184693