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579050 TAPI-0 - CAS 143457-40-3 - Calbiochem

TAPI-0, CAS 143457-40-3, is a hydroxamate-based inhibitor of collagenase, gelatinase, and TACE (TNF-α converting enzyme/ADAM17; IC₅₀ = 100 nM).

TAPI-0 - CAS 143457-40-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine Amide, TNF-α Protease Inhibitor-0

Primary Target: TNF-α converting enzyme/ADAM17
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579050
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
143457-40-3C₂₄H₃₂N₄O₅

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579050-1MG
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      		 Plastic ampoule 1 mg
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      Description
      OverviewA hydroxamate-based inhibitor of collagenase, gelatinase, and TACE (TNF-α converting enzyme/ADAM17; IC50 = 100 nM). Blocks spontaneous and PMA-induced release of TNF-α in transfected COS 7 cells.
      Catalogue Number579050
      Brand Family Calbiochem®
      SynonymsN-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine Amide, TNF-α Protease Inhibitor-0
      References
      ReferencesHooper, N.M., et al. 1997. Biochem. J. 321, 265.
      Mullberg, J., et al. 1995. J. Immunol. 155, 5198.
      Mohler, K.M., et al. 1994. Nature 370, 218.
      Product Information
      CAS number143457-40-3
      ATP CompetitiveN
      DeclarationManufactured exclusively by Peptides International, Louisville, Kentucky, USA.
      FormWhite solid
      Hill FormulaC₂₄H₃₂N₄O₅
      Chemical formulaC₂₄H₃₂N₄O₅
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetTNF-α converting enzyme/ADAM17
      Primary Target IC<sub>50</sub>100 nM against TACE (TNF-α converting enzyme/ADAM17)
      Purity≥96% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      579050-1MG 04055977265354

      Documentation

      TAPI-0 - CAS 143457-40-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      TAPI-0 - CAS 143457-40-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      579050

      References

      Reference overview
      Hooper, N.M., et al. 1997. Biochem. J. 321, 265.
      Mullberg, J., et al. 1995. J. Immunol. 155, 5198.
      Mohler, K.M., et al. 1994. Nature 370, 218.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-April-2008 RFH
      SynonymsN-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine Amide, TNF-α Protease Inhibitor-0
      DescriptionA hydroxymate-based inhibitor of collagenase, gelatinase, and TACE [(TNF-α convertase; ADAM17 (IC50 = 100 nM)]. Blocks spontaneous and PMA-induced release of TNF-α from transfected COS-7 cells.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number143457-40-3
      Chemical formulaC₂₄H₃₂N₄O₅
      Structure formulaStructure formula
      Purity≥96% by HPLC
      Solubility50% acetic acid (1 mg/ml) or DMSO (5 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesHooper, N.M., et al. 1997. Biochem. J. 321, 265.
      Mullberg, J., et al. 1995. J. Immunol. 155, 5198.
      Mohler, K.M., et al. 1994. Nature 370, 218.