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574661 Survivin Antagonist, S12 - CAS 258264-62-9 - Calbiochem

The Survivin Antagonist, S12 controls the biological activity of Survivin.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Survivin Inhibitor II, 3-(2-(benzo[d][1,3]dioxol-5-yl)-2-oxoethyl)-5-bromo-3-hydroxyindolin-2-one

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574661
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
258264-62-9C₁₇H₁₂BrNO₅

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574661-10MG
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      Description
      OverviewA cell-permeable hydroxyindolinone compound that acts as a selective antagonist of survivin. Induces mitotic arrest and blocks cell cycle at G2/M phase (~40 µM in HeLA cells) leading to apoptotic cell death. Shown to bind to a specific cavity adjacent to the interface involved in the dimerization of survivin. Binding is specific only to native survivin and does not affect any mutant forms. Inhibits HCT116 cell proliferation independently of their p53 status and reduces tumor volume in xenograft models in a dose-dependent manner (5 to 15 mg/kg).
      Catalogue Number574661
      Brand Family Calbiochem®
      SynonymsSurvivin Inhibitor II, 3-(2-(benzo[d][1,3]dioxol-5-yl)-2-oxoethyl)-5-bromo-3-hydroxyindolin-2-one
      References
      ReferencesBerezov, A., et al. 2011. Oncogene 31, 1938.
      Product Information
      CAS number258264-62-9
      FormWhite solid
      Hill FormulaC₁₇H₁₂BrNO₅
      Chemical formulaC₁₇H₁₂BrNO₅
      HS Code2934 99 99
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      574661-10MG 04055977189643

      Documentation

      Survivin Antagonist, S12 - CAS 258264-62-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Survivin Antagonist, S12 - CAS 258264-62-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      574661

      References

      Reference overview
      Berezov, A., et al. 2011. Oncogene 31, 1938.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-June-2012 JSW
      SynonymsSurvivin Inhibitor II, 3-(2-(benzo[d][1,3]dioxol-5-yl)-2-oxoethyl)-5-bromo-3-hydroxyindolin-2-one
      DescriptionA cell-permeable hydroxyindolinone compound that acts as a selective antagonist of survivin. Induces mitotic arrest and blocks cell cycle at G2/M phase (~40 µM in HeLA cells) leading to apoptotic cell death. Shown to bind to a specific cavity adjacent to the interface involved in the dimerization of survivin. Binding is specific only to native survivin and does not affect any mutant forms. Inhibits HCT116 cell proliferation independently of their p53 status and reduces tumor volume in xenograft models in a dose-dependent manner (5 to 15 mg/kg).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number258264-62-9
      Chemical formulaC₁₇H₁₂BrNO₅
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml; nearly colorless solution)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBerezov, A., et al. 2011. Oncogene 31, 1938.