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324813 Soluble Epoxide Hydrolase Inhibitor, NCND - CAS 402939-18-8 - Calbiochem

The Soluble Epoxide Hydrolase Inhibitor, NCND, also referenced under CAS 402939-18-8, controls the biological activity of Soluble Epoxide Hydrolase.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: CDU, N-Cyclohexyl-Nʹ-dodecylurea, 1-Cyclohexyl-3ʹ-dodecylurea

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324813
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      Description
      OverviewA cell-permeable 1,3-disubstituted urea compound that displays anti-hypertensive and anti-inflammatory properties. Acts as a potent, selective, competitive, and tight-binding transition-state analog inhibitor of soluble epoxide hydrolase (sEH; IC50 = 9.8 nM for mouse recombinant sEH, 85.2 nM for human recombinant sEH). Reported to decrease human VSMC (vascular smooth muscle cell) proliferation.
      Catalogue Number324813
      Brand Family Calbiochem®
      SynonymsCDU, N-Cyclohexyl-Nʹ-dodecylurea, 1-Cyclohexyl-3ʹ-dodecylurea
      References
      ReferencesNewman, J.W., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 1558.
      Davis, B.B., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 2222.
      Morisseau, C., et al. 2002. Biochem. Pharmacol. 63, 1599.
      Imig, J.D., et al. 2002. Hypertension 39, 690.
      Argiriadi, M.A., et al. 2000. J. Biol. Chem. 275, 15265.
      Yu, Z., et al. 2000. Circ. Res. 87, 992.
      Product Information
      CAS number402939-18-8
      ATP CompetitiveY
      FormWhite solid
      Hill FormulaC₁₉H₃₈N₂O
      Chemical formulaC₁₉H₃₈N₂O
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetSoluble epoxide hydrolase
      Primary Target IC<sub>50</sub>9.8 nM for mouse recombinant sEH, 85.2 nM for human recombinant sEH
      Purity≥95% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      324813-25MG 04055977216172

      Documentation

      Soluble Epoxide Hydrolase Inhibitor, NCND - CAS 402939-18-8 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Soluble Epoxide Hydrolase Inhibitor, NCND - CAS 402939-18-8 - Calbiochem Certificates of Analysis

      TitleLot Number
      324813

      References

      Reference overview
      Newman, J.W., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 1558.
      Davis, B.B., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 2222.
      Morisseau, C., et al. 2002. Biochem. Pharmacol. 63, 1599.
      Imig, J.D., et al. 2002. Hypertension 39, 690.
      Argiriadi, M.A., et al. 2000. J. Biol. Chem. 275, 15265.
      Yu, Z., et al. 2000. Circ. Res. 87, 992.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-April-2011 RFH
      SynonymsCDU, N-Cyclohexyl-Nʹ-dodecylurea, 1-Cyclohexyl-3ʹ-dodecylurea
      DescriptionA cell-permeable, potent, selective, competitive, and tight binding transition-state analog inhibitor of soluble epoxide hydrolase (sEH) (IC50 = 9.8 nM for recombinant murine sEH and 85.2 nM for recombinant human sEH). Also displays anti-hypertensive and anti-inflammatory properties. Reported to decrease human vascular smmoth muscle cell (VSMC) proliferation.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number402939-18-8
      Chemical formulaC₁₉H₃₈N₂O
      Structure formulaStructure formula
      Purity≥95% by TLC
      SolubilityCH₂Cl₂ (1 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesNewman, J.W., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 1558.
      Davis, B.B., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 2222.
      Morisseau, C., et al. 2002. Biochem. Pharmacol. 63, 1599.
      Imig, J.D., et al. 2002. Hypertension 39, 690.
      Argiriadi, M.A., et al. 2000. J. Biol. Chem. 275, 15265.
      Yu, Z., et al. 2000. Circ. Res. 87, 992.