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SCC458 SCp2 Mouse Mammary Epithelial Cell Line

SCp2 cell line is useful for the study of normal and abnormal mammary epithelial cell phenotypes

SCC458
≥1X10⁶ cells/vial   
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      Overview

      Description
      Catalogue NumberSCC458
      DescriptionSCp2 Mouse Mammary Epithelial Cell Line
      Background InformationMammary epithelial cell differentiation and reorganization occurs throughout development and in the adult organ during pregnancy and menopause. During these periods in the adult life there is an increased risk for breast cancer, which is the most frequent cancer in women. Breast cancer can be curable when detected at early stages, but it is considered incurable in advance stages with metastasis. The extracellular matrix (ECM) in mammary tissue influences growth and differentiation during development, differentiation, and carcinogenesis (1). Epithelial cells sense ECM modifications through transmembrane receptors like integrins that can influence the expression of malignant phenotypes like increased proliferation and loss of contact inhibition growth (1).

      The SCp2 cell line was isolated from the heterogenous CID9 cells by limiting dilution cloning (2). CID9 cells were isolated from a midpregnancy mouse mammary gland. SCp2 cells require exogenously added ECM and lactogenic hormones to express b-casein, under these conditions the cells arrest growth, aggregate, and form alveolar structures that express high levels of milk proteins (2). SCp2 cells are useful to study normal and abnormal mammary epithelial cell phenotypes because their growth and differentiation can be controlled in culture. Activated mutants of M-Ras have been introduced in normal SCp2 cells to study transformation, invasion, and tumor formation in vivo (3).

      Source
      SCp2 is a murine mammary epithelial cell line that originated from limiting dilution cloning of heterogenous CID9 cells.

      References
      1. Int J Biochem Cell Biol 2007, 39(11): 1987-1994.
      2. Proc Natl Acad Sci USA 1994, 91(26): 12378-12382.
      3. Oncogene 2004, 23(6): 1187-1196.
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationSCp2 cell line is useful for the study of normal and abnormal mammary epithelial cell phenotypes
      Key Applications
      • Cell Culture
      Application NotesThis product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.
      Biological Information
      Cell Line Type
      • Epithelial Cells
      Product Usage Statements
      Quality AssuranceEach vial contains ≥1X10⁶ viable cells.

      Cells are tested negative for infectious diseases by a Mouse Essential CLEAR Panel by Charles River Animal Diagnostic Services.

      Cells are verified to be of mouse origin and negative for inter-species contamination from rat, human, Chinese hamster, Golden Syrian hamster, and Non-human Primate (NHP) as assessed by a Contamination Clear panel by Charles River Animal Diagnostic Services

      Cells are negative for mycoplasma contamination.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsCells should be stored in liquid nitrogen until use. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
      Packaging Information
      Material Size≥1X10⁶ cells/vial
      Global Trade Item Number
      Catalogue Number GTIN
      SCC458 04065267034638