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14-480M Rsk2/MAPKAP Kinase 1b Protein, active, 250 µg

Active, recombinant human RSK2, full-length with an N-terminal His6 tag between Met1 & Pro2, for use in Kinase Assays.

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14-480M
250 µg  Also available in 10 μg size (cat#14-480) and in bulk (cat# 14-480-K).
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      Overview

      Description
      Catalogue Number14-480M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionRsk2/MAPKAP Kinase 1b Protein, active, 250 µg
      OverviewRecombinant human RSK2, full-length with an N-terminal His6 tag between Met1 and Pro2
      Product Information
      Quality LevelMQ300
      Applications
      ApplicationActive, recombinant human RSK2, full-length with an N-terminal His6 tag between Met1 & Pro2, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceExpressed by baculovirus in Sf21 insect cells
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS).
      Gene Symbol
      • RPS6KA3
      • CLS
      • RSK-2
      • RSK2
      • p90-RSK2
      • ISPK1
      • MRX19
      • HU-3
      • pp90RSK2
      • MAPKAPK1B
      • HU-2
      • RSK
      • S6K-alpha3
      • ISPK-1
      Protein TargetRsk2
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyAGC
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P51812 # Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.
      COFACTOR: Magnesium (By similarity).
      SIZE: 740 amino acids; 83736 Da
      SUBUNIT: Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation (By similarity).
      TISSUE SPECIFICITY: Expressed in many tissues, highest levels in skeletal muscle.
      PTM: Autophosphorylated on Ser-386, as part of the activation process (By similarity). & Ser-227 phosphorylation promotes Ser-386 phosphorylation and leads to basal activation. Full activation by growth factors requires additional phosphorylation on Ser-369 (By similarity).
      DISEASE: SwissProt: P51812 # Defects in RPS6KA3 are the cause of Coffin-Lowry syndrome (CLS) [MIM:303600]; an X-linked dominant disorder characterized by severe mental retardation with facial and digital dysmorphisms, and progressive skeletal deformations.
      SIMILARITY: SwissProt: P51812 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 2 protein kinase domains.
      Molecular Weight88kDa
      Product Usage Statements
      Quality Assurancethe MAPKAP Kinase 2 substrate peptide
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions1 year at -70C
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-480) and in bulk (cat# 14-480-K).
      Global Trade Item Number
      Catalogue Number GTIN
      14-480M 04053252322211