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556770 RNase L Activator - CAS 357618-26-9 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: C-5950331

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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      357618-26-9C₁₆H₁₄N₂O₂S
      Description
      Overview

      This product has been discontinued.



      A cell-permeable tricyclic fused phenolic compound that induces RNase L dimerization and activation (EC50 = 22 µM) via direct interaction (KD = 12 µM) at the natural activator 2-5A (5'-phosphorylated, 2',5'-oligoadenylates) binding domain. Shown to exhibit broad-spectrum antiviral activity against diverse types of RNA viruses in both murine (EMCV & VSV in MEF) and human (HPIV-3, Sandai, XMRV in HeLa M, HeLa S, and DU145, respectively) cultures, but not in RNase L-deficient MEF culture or HeLa cells expressing inactive RNase L. Although the synthetic compound binds RNase L with a 4- to 6-times slower kinetic and is 44,000-times less potent than a trimer 2-5A (p3A2'p5'A2'p5'A), it is much more permeant and displays no cytotoxicity to MEF or HeLa S cells (50 µM for 24 h).
      Catalogue Number556770
      Brand Family Calbiochem®
      SynonymsC-5950331
      References
      ReferencesThakur, C.S., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 9585.
      Product Information
      CAS number357618-26-9
      FormOff-white solid
      Hill FormulaC₁₆H₁₄N₂O₂S
      Chemical formulaC₁₆H₁₄N₂O₂S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      556770 0

      Documentation

      RNase L Activator - CAS 357618-26-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      RNase L Activator - CAS 357618-26-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      556770

      References

      Reference overview
      Thakur, C.S., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 9585.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      SynonymsC-5950331
      DescriptionA cell-permeable tricyclic fused phenolic compound that induces RNase L dimerization and activation (EC50 = 22 µM) via direct interaction (KD = 12 µM) at the natural activator 2-5A (5'-phosphorylated, 2',5'-oligoadenylates) binding domain. Shown to exhibit broad-spectrum antiviral activity against diverse types of RNA viruses in both murine (EMCV & VSV in MEF) and human (HPIV-3, Sandai, XMRV in HeLa M, HeLa S, and DU145, respectively) cultures, but not in RNase L-deficient MEF culture or HeLa cells expressing inactive RNase L. Although the synthetic compound binds RNase L with a 4- to 6-times slower kinetic and is 44,000-times less potent than a trimer 2-5A (p3A2'p5'A2'p5'A), it is much more permeant and displays no cytotoxicity to MEF or HeLa S cells (50 µM for 24 h).
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number357618-26-9
      Chemical formulaC₁₆H₁₄N₂O₂S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (25 mg/ml) or Ethanol (2.5 mg/ml at 50-60°C water-bath)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesThakur, C.S., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 9585.