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5291 Polymyxin B Sulfate - CAS 1405-20-5 - Calbiochem

Polymyxin B Sulfate, CAS 1405-20-5, is an antibiotic that is effective against Gram-positive bacteria. Inhibits phospholipid-sensitive Ca2+-dependent protein kinases.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Aerosporin

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      Overview

      Key Spec Table

      CAS #
      1405-20-5
      Description
      OverviewAn antibiotic that inhibits phospholipid-sensitive Ca2+-dependent protein kinases. Mixture of polymyxin B1 sulfate and polymyxin B2 sulfate. Binds to cell wall and makes it more permeable, causing fluid uptake. Effective against Gram-negative bacteria.
      Catalogue Number5291
      Brand Family Calbiochem®
      SynonymsAerosporin
      References
      ReferencesLucas, M., et al. 1994. Biochem. Pharmacol. 47, 667.
      Ngezahayo, A. and Kolb, H.A. 1993. Pflugers Arch. 422, 413.
      Kubo, M. and Okada, Y. 1992. J. Physiol. 456, 351.
      Strasser, S.H., et al. 1992. Circ. Res. 70, 1304.
      Hegemann, L., et al. 1991. Eur. J. Pharmacol. 207, 17.
      Inaba, H. and Filkins, J.P. 1991. Am. J. Physiol. 261, R26.
      Marra, M.N., et al. 1990. J. Immunol. 144, 662.
      Product Information
      CAS number1405-20-5
      FormWhite to off-white solid
      Quality LevelMQ200
      Biological Information
      Biological activityPotency: ≥7500 IU/mg
      Primary TargetPhospholipid sensitive Ca2+ dependent protein kinases
      Safety Information according to GHS
      RTECSTR1150000
      Safety Information
      R PhraseR: 22

      Harmful if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 year at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      5291 0