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527948 Piceatannol - CAS 10083-24-6 - Calbiochem

A cell-permeable, substrate competitive and reversible plant metabolite that inhibits the activity of rat liver protein kinase A catalytic subunit (IC₅₀ = 3 µM), PKC (IC₅₀ = 8 µM), MLCK (IC₅₀ = 12 µM).

Piceatannol - CAS 10083-24-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: trans-3,3ʹ,4,5ʹ-Tetrahydroxystilbene

Primary Target: Activity of rat liver protein kinase A catalytic subunit
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      10083-24-6C₁₄H₁₂O₄
      Description
      OverviewA cell-permeable, substrate competitive and reversible plant metabolite that inhibits the activity of rat liver protein kinase A catalytic subunit (IC50 = 3 µM), PKC (IC50 = 8 µM), MLCK (IC50 = 12 µM). In RBL-2H3 cells, the selective inhibition of Syk by piceatannol results in inhibition of FceR1-mediated signaling. Also inhibits wheat embryo Ca2+-dependent protein kinase (CDPK) (IC50 = 19 µM), and p72syk (IC50 = 10 µM), a non-receptor tyrosine kinase, relative to Lyn in isolated enzyme preparations. Also possesses anti-leukemic properties. Reported to activate sirtuins and promote the survival of eukaryotic cells.
      Catalogue Number527948
      Brand Family Calbiochem®
      Synonymstrans-3,3ʹ,4,5ʹ-Tetrahydroxystilbene
      References
      ReferencesHowitz, K.T., et al. 2003. Nature 425, 191.
      Wang, B.H., et al. 1998. Planta Med. 64, 195.
      Keely, P.J., and Parise, L.V. 1996. J. Biol. Chem. 271, 26668.
      Oliver, J.M., et al. 1994. J. Biol. Chem. 269, 29697.
      Thakkar, K., et al. 1993. J. Med. Chem. 36, 2950.
      Geahlen, R.L., et al. 1989. Biochem. Biophys. Res. Commun. 165, 241.
      Product Information
      CAS number10083-24-6
      ATP CompetitiveY
      FormOff-white crystalline solid
      Hill FormulaC₁₄H₁₂O₄
      Chemical formulaC₁₄H₁₂O₄
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetActivity of rat liver protein kinase A catalytic subunit
      Primary Target IC<sub>50</sub>3 µM, 8 µM, and 12 µM against the activity of rat liver protein kinase A catalytic subunit, PKC, and MLCK, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot, flush with an inert gas, and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      527948 0

      Documentation

      Piceatannol - CAS 10083-24-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Piceatannol - CAS 10083-24-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      527948

      References

      Reference overview
      Howitz, K.T., et al. 2003. Nature 425, 191.
      Wang, B.H., et al. 1998. Planta Med. 64, 195.
      Keely, P.J., and Parise, L.V. 1996. J. Biol. Chem. 271, 26668.
      Oliver, J.M., et al. 1994. J. Biol. Chem. 269, 29697.
      Thakkar, K., et al. 1993. J. Med. Chem. 36, 2950.
      Geahlen, R.L., et al. 1989. Biochem. Biophys. Res. Commun. 165, 241.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-March-2010
      Synonymstrans-3,3ʹ,4,5ʹ-Tetrahydroxystilbene
      DescriptionA cell-permeable, substrate competitive, and reversible plant metabolite that inhibits the activity of rat liver protein kinase A catalytic subunit (IC50 = 3 µM), PKC (IC50 = 8 µM), MLCK (IC50 = 12 µM). In RBL-2H3 cells, the selective inhibition of Syk by piceatannol results in inhibition of FceR1-mediated signaling. Also inhibits wheat embryo Ca2+-dependent protein kinase (CDPK) (IC50 = 19 µM), and p72syk (IC50 = 10 µM), a non-receptor tyrosine kinase, relative to Lyn in isolated enzyme preparations. Also possesses anti-leukemic properties. Reported to activate sirtuins and promote the survival of eukaryotic cells.
      FormOff-white crystalline solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number10083-24-6
      Chemical formulaC₁₄H₁₂O₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml) or Ethanol (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot, flush with an inert gas, and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
      Toxicity Standard Handling
      ReferencesHowitz, K.T., et al. 2003. Nature 425, 191.
      Wang, B.H., et al. 1998. Planta Med. 64, 195.
      Keely, P.J., and Parise, L.V. 1996. J. Biol. Chem. 271, 26668.
      Oliver, J.M., et al. 1994. J. Biol. Chem. 269, 29697.
      Thakkar, K., et al. 1993. J. Med. Chem. 36, 2950.
      Geahlen, R.L., et al. 1989. Biochem. Biophys. Res. Commun. 165, 241.

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      Categories

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase C (PKC) Inhibitors
      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Myosin Light Chain Kinase (MLCK) Inhibitors
      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase A (PKA; cAMP-Dependent Protein Kinase) Inhibitors
      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Tyrosine Kinase (PTK) Inhibitors