Millipore Sigma Vibrant Logo

524390 Phorbol-12,13-dibutyrate - CAS 37558-16-0 - Calbiochem

Strong irritant for mouse skin, but only moderately active as a tumor promoter.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PDBu, PKC Activator II

Primary Target: Na+,K+- ATPase
View Products on Sigmaaldrich.com
524390
View Pricing & Availability

Overview

Key Spec Table

CAS #Empirical Formula
37558-16-0C₂₈H₄₀O₈

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
524390-1MG
—
Limited Availability Limited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      		 Alu drum 1 mg
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      —
      Request Pricing
      		 —
      Add To Favorites
      524390-5MG
      —
      Limited Availability Limited Availability
      In Stock 
      Discontinued
      Limited Quantities Available
      Availability to be confirmed
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          		 Alu drum 5 mg
          Price could not be retrieved
          Minimum Quantity is a multiple of
          Maximum Quantity is
          Upon Order Completion More Information
          You Saved ()
           
          —
          Request Pricing
          		 —
          Add To Favorites
          Description
          OverviewStrong irritant for mouse skin, but only moderately active as a tumor promoter. Activates protein kinase C. Stimulates the phosphorylation of Na+,K+- ATPase, thereby inhibiting its activity. Promotes the expression of inducible NOS in cultured hepatocytes. Commonly used in binding studies or in applications requiring high concentrations of phorbol compounds.
          Catalogue Number524390
          Brand Family Calbiochem®
          SynonymsPDBu, PKC Activator II
          References
          ReferencesFisone, G., et al. 1995. J. Biol. Chem. 270, 2427.
          Lee, E.J., et al. 1994. Brain Res. 665, 127.
          Critz, S.D., et al. 1993. J. Neurochem. 60, 1175.
          Iredale, P.A., et al. 1993. Biochem. Pharmacol. 45, 611.
          Critz, S.D., and Byrne J.H. 1992. J. Neurophys. 68, 1079.
          Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
          Ward C.A., and Moffat, M.P. 1992. J. Mol. Cell. Cardiol. 24, 937.
          Product Information
          CAS number37558-16-0
          ATP CompetitiveN
          FormWhite to light yellow solid
          Hill FormulaC₂₈H₄₀O₈
          Chemical formulaC₂₈H₄₀O₈
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Biological Information
          Primary TargetNa+,K+- ATPase
          Purity≥99% by HPLC
          Physicochemical Information
          Cell permeableN
          Safety Information according to GHS
          RTECSEK7767000
          Safety Information
          R PhraseR: 26/27/28-36/37/38-40-41

          Very toxic by inhalation, in contact with skin and if swallowed.
          Irritating to eyes, respiratory system and skin.
          Limited evidence of a carcinogenic effect.
          Risk of serious damage to eyes.
          S PhraseS: 26-36/37/39-45

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Highly Toxic & Carcinogenic / Teratogenic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C. With frequent use, the DMSO stock solutions may accumulate water. The presence of water in the stock solution will accelerate the decomposition of the product, resulting in significant loss of activity in 2-3 months.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Global Trade Item Number
          Catalogue Number GTIN
          524390-1MG 04055977271546
          524390-5MG 04055977271553