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528113 PI 3-Kβ Inhibitor VI, TGX-221 - CAS 663619-89-4 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (±)-7-Methyl-2-(morpholin-4-yl)-9-(1-phenylaminoethyl)-pyrido[1,2-a]-pyrimidin-4-one, PI 3-K Inhibitor VI

Primary Target: PI 3-Kβ
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      663619-89-4C₂₁H₂₄N₄O₂
      Description
      Overview

      This product has been discontinued.



      A cell-permeable morpholino-pyrimidinone compound that acts as a reversible, ATP-competitive, selective, and highly potent inhibitor of PI 3-Kβ (IC50 = 0.005, 0.1, 5, and ≥3.5 µM for -β, -δ, -α and -γ isoforms, respectively) with little activity against a panel of 15 commonly studied protein kinases even at concentrations as high as 10.0 µM. An excellent tool for studying p110β-dependent responses both in cells in vitro and in animals in vivo.
      Catalogue Number528113
      Brand Family Calbiochem®
      Synonyms(±)-7-Methyl-2-(morpholin-4-yl)-9-(1-phenylaminoethyl)-pyrido[1,2-a]-pyrimidin-4-one, PI 3-K Inhibitor VI
      References
      ReferencesChaussade, C., et al. 2007. Biochem. J. 404, 449.
      Cosemans, J.M, et al. 2006. Blood 108, 3045.
      Condliffe, A.M., et al. 2005. Blood 106, 1432.
      Jackson, S.P., et al. 2005. Nat. Med. 11, 507.
      Product Information
      CAS number663619-89-4
      ATP CompetitiveY
      FormWhite solid
      Hill FormulaC₂₁H₂₄N₄O₂
      Chemical formulaC₂₁H₂₄N₄O₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPI 3-Kβ
      Primary Target IC<sub>50</sub>0.005, 0.1, 5, and ≥3.5 µM for -β, -δ, -α and -γ isoforms, respectively
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      528113 0

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      PI 3-Kβ Inhibitor VI, TGX-221 - CAS 663619-89-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Chaussade, C., et al. 2007. Biochem. J. 404, 449.
      Cosemans, J.M, et al. 2006. Blood 108, 3045.
      Condliffe, A.M., et al. 2005. Blood 106, 1432.
      Jackson, S.P., et al. 2005. Nat. Med. 11, 507.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-January-2008 JSW
      Synonyms(±)-7-Methyl-2-(morpholin-4-yl)-9-(1-phenylaminoethyl)-pyrido[1,2-a]-pyrimidin-4-one, PI 3-K Inhibitor VI
      DescriptionA cell-permeable morpholino-pyrimidinone compound that acts as a reversible, ATP-competitive, selective, and highly potent inhibitor of PI 3-Kβ (IC50 = 0.005, 0.1, 5, and ≥3.5 µM for -β, -δ, -α and -γ isoforms, respectively) with little activity against a panel of 15 commonly studied protein kinases even at concentrations as high as 10.0 µM. An excellent tool for studying p110β-dependent responses both in cells in vitro and in animals in vivo.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number663619-89-4
      Chemical formulaC₂₁H₂₄N₄O₂
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesChaussade, C., et al. 2007. Biochem. J. 404, 449.
      Cosemans, J.M, et al. 2006. Blood 108, 3045.
      Condliffe, A.M., et al. 2005. Blood 106, 1432.
      Jackson, S.P., et al. 2005. Nat. Med. 11, 507.