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528819 PARP Inhibitor XI, DR2313

The PARP Inhibitor XI, DR2313, also referenced under CAS 284028-90-6, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

PARP Inhibitor XI, DR2313 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidine-4-one

Primary Target: PARP
528819
  
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      284028-90-6C₈H₁₀N₂OS
      Description
      Overview

      This product has been discontinued.





      A brain-permeable and water soluble pyrimidinone compound that acts as a potent and NAD+-competitive inhibitor of PARP (IC50 = 200 nM and 240 nM for rhPARP1 and rmPARP2, respectively) with little activity against the dehydrogenase activity of GAPDH, ADH, LDH, or the ADP-ribosylase activity of bacterial diphtheria toxin even at concentrations as high as 10 µM. Shown to inhibit H2O2-induced PAR formation and neuronal cell death in primary rat cerebral cortex culture in vitro (EC50 = 270 nM) and exhibit neuroprotective effects in both permanent and transient focal ischemia models in rat in in vivo.
      Catalogue Number528819
      Brand Family Calbiochem®
      Synonyms2-Methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidine-4-one
      References
      ReferencesNakajima, H., et al. 2005. J. Pharmacol. Exp. Ther. 312, 472.
      Product Information
      CAS number284028-90-6
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₈H₁₀N₂OS
      Chemical formulaC₈H₁₀N₂OS
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetPARP
      Primary Target IC<sub>50</sub>200 nM and 240 nM for rhPARP1 and rmPARP2, respectively
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      528819 0

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      PARP Inhibitor XI, DR2313 SDS

      Title

      Safety Data Sheet (SDS) 

      PARP Inhibitor XI, DR2313 Certificates of Analysis

      TitleLot Number
      528819

      References

      Reference overview
      Nakajima, H., et al. 2005. J. Pharmacol. Exp. Ther. 312, 472.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-August-2008 RFH
      Synonyms2-Methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidine-4-one
      DescriptionA brain-permeable and water soluble pyrimidinone compound that acts as a potent and NAD+-competitive inhibitor of PARP (IC50 = 200 nM and 240 nM for rhPARP1 and rmPARP2, respectively) with little activity against the dehydrogenase activity of GAPDH, ADH, LDH, or the ADP-ribosylase activity of bacterial diphtheria toxin even at concentrations as high as 10 µM. Shown to inhibit H2O2-induced PAR formation and neuronal cell death in primary rat cerebral cortex culture in vitro (EC50 = 270 nM) and exhibit neuroprotective effects in both permanent and transient focal ischemia models in rat in in vivo.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number284028-90-6
      Chemical formulaC₈H₁₀N₂OS
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O (30 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesNakajima, H., et al. 2005. J. Pharmacol. Exp. Ther. 312, 472.