517301 Sigma-AldrichP-Glycoprotein Inhibitor, C-4 - CAS 864426-22-2 - Calbiochem
The P-Glycoprotein Inhibitor, C-4 controls the biological activity of P-Glycoprotein. This small molecule/inhibitor is primarily used for Cancer applications.
More>> The P-Glycoprotein Inhibitor, C-4 controls the biological activity of P-Glycoprotein. This small molecule/inhibitor is primarily used for Cancer applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: (E)-4-Chloro-N-(3-(3-(4-hydroxy-3-methoxyphenyl)acryloyl)phenyl)benzamide, C-4
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 864426-22-2 | C₂₃H₁₈ClNO₄ |
Pricing & Availability
| Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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| 517301-10MG |
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Plastic ampoule | 10 mg |
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| Description | |
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| Overview | A cell-permeable cinnamoyl compound that reversibly inhibits P-gp (P-glycoprotein) efflux function and reverses the MDR (multidrug resistance) phenotype with no noticeable effect on P-gp expression. Shown to significantly enhance Paclitaxel- (Cat. No. 580555) and Vincristine- (Cat. No. 677181) induced cytotoxicity as well as apoptosis in P-gp expressing KBV20C cells. |
| Catalogue Number | 517301 |
| Brand Family | Calbiochem® |
| Synonyms | (E)-4-Chloro-N-(3-(3-(4-hydroxy-3-methoxyphenyl)acryloyl)phenyl)benzamide, C-4 |
| References | |
|---|---|
| References | Kim, Y.K., et al. 2007. Biochem. Biophys. Res. Commun. 355, 136. Woo, H.B., et al. 2005. Bioorg. Med. Chem. Lett. 15, 3782. |
| Product Information | |
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| CAS number | 864426-22-2 |
| ATP Competitive | N |
| Form | Yellow solid |
| Hill Formula | C₂₃H₁₈ClNO₄ |
| Chemical formula | C₂₃H₁₈ClNO₄ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | P-Glycoprotein |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 517301-10MG | 04055977271874 |
Documentation
P-Glycoprotein Inhibitor, C-4 - CAS 864426-22-2 - Calbiochem SDS
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P-Glycoprotein Inhibitor, C-4 - CAS 864426-22-2 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 517301 |
References
| Reference overview |
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| Kim, Y.K., et al. 2007. Biochem. Biophys. Res. Commun. 355, 136. Woo, H.B., et al. 2005. Bioorg. Med. Chem. Lett. 15, 3782. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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