Our broad portfolio consists of multiplex panels that allow you to choose, within the panel, analytes that best meet your needs. On a separate tab you can choose the premixed cytokine format or a single plex kit.
Cell Signaling Kits & MAPmates™
Choose fixed kits that allow you to explore entire pathways or processes. Or design your own kits by choosing single plex MAPmates™, following the provided guidelines.
The following MAPmates™ should not be plexed together:
-MAPmates™ that require a different assay buffer
-Phospho-specific and total MAPmate™ pairs, e.g. total GSK3β and GSK3β (Ser 9)
-PanTyr and site-specific MAPmates™, e.g. Phospho-EGF Receptor and phospho-STAT1 (Tyr701)
-More than 1 phospho-MAPmate™ for a single target (Akt, STAT3)
-GAPDH and β-Tubulin cannot be plexed with kits or MAPmates™ containing panTyr
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48-602MAG
Buffer Detection Kit for Magnetic Beads
1 Kit
Space Saver Option Customers purchasing multiple kits may choose to save storage space by eliminating the kit packaging and receiving their multiplex assay components in plastic bags for more compact storage.
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505758
Sigma-AldrichOxidized ATP (oATP) - CAS 71997-40-5 - Calbiochem
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Description
Overview
A 2′,3′-dialdehyde derivative of ATP that is commonly used to affinity label nucleotide sites in enzymes. Acts as a specific, irreversible antagonist of P2Z/P2X7 purinergic receptors in J774 mouse macrophages. Does not affect P2γ receptors. Inhibits inflammatory pain in arthritic rat model by blocking ATP action on P2X7 receptor in nerve terminals. Also shown to irreversibly block ATP-induced Ca2+ influx in lymphocytes (˜100 µM). O-ATP-treated mice display better preservation and lower rate of rejection of pancreatic islet grafts with reduced Th1 transcripts.
Vergani, A., et al. 2013. Diabetes62, 1665. DellʹAntonio, G., et al. 2002. Arthritis Rheum.46, 3378. Wiley, J.S., et al. 1994. Br. J. Pharmacol.112, 946. Murgia, M., et al. 1992. J. Biol. Chem.268, 8199.
Vergani, A., et al. 2013. Diabetes62, 1665. DellʹAntonio, G., et al. 2002. Arthritis Rheum.46, 3378. Wiley, J.S., et al. 1994. Br. J. Pharmacol.112, 946. Murgia, M., et al. 1992. J. Biol. Chem.268, 8199.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
A 2′,3′-dialdehyde derivative of ATP that is commonly used to affinity label nucleotide sites in enzymes. Acts as a specific, irreversible antagonist of P2Z/P2X7 purinergic receptors in J774 mouse macrophages. Does not affect P2γ receptors. Inhibits inflammatory pain in arthritic rat model by blocking ATP action on P2X7 receptor in nerve terminals. Also shown to irreversibly block ATP-induced Ca2+ influx in lymphocytes (˜100 µM). O-ATP-treated mice display better preservation and lower rate of rejection of pancreatic islet grafts with reduced Th1 transcripts.
Form
White powder
CAS number
71997-40-5
Chemical formula
C₁₀H₁₄N₅O₁₃P₃
Structure formula
Purity
≥97% by HPLC
Solubility
H₂O (50 mg/ml)
Storage
Protect from light -20°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Standard Handling
References
Vergani, A., et al. 2013. Diabetes62, 1665. DellʹAntonio, G., et al. 2002. Arthritis Rheum.46, 3378. Wiley, J.S., et al. 1994. Br. J. Pharmacol.112, 946. Murgia, M., et al. 1992. J. Biol. Chem.268, 8199.
