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SCC642 OCUG-1 Human Gallbladder Carcinoma Cell Line

The OCUG-1 human gallbladder carcinoma cell line has been used to study hapatobiliary cancer in genome-wide mutation and expression studies.

NewSCC642
≥1X10⁶ cells/vial   
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      Overview

      Replacement Information
      Description
      Catalogue NumberSCC642
      DescriptionOCUG-1 Human Gallbladder Carcinoma Cell Line
      Alternate Names
      • OCUG1
      • Osaka City University Gallbladder-1
      Background InformationSCC642 (OCUG-1), the human gallbladder carcinoma cell line, was isolated from the peritoneal effusion of a Japanese male patient with malignant gallbladder carcinoma. Although the primary tumor was diagnosed as a poorly differentiated adenocarcinoma, and the reconstituted tumors in nude mice also exhibited the same histologic characteristics, the OCUG-1 cells were found to abundantly express the Tumor-Associated Antigen 4 (TA-4), which had been identified as a serum marker for cervical squamous cell carcinoma. This led Yamada et al. to propose that OCUG-1 might be a transitional form between adenocarcinoma and squamous cell carcinoma and represented a useful model system for investigating the squamatization processes. Subsequently, one of the major components of TA-4, the Squamous Cell Carcinoma Antigen 1 (SCCA1, also known as SERPINB3, the Serine Protease Inhibitor Clade B Member 3), was shown to induce the squamatization and disease progression in pancreatic cancer by the inhibition of the degradation of the MYC proto-oncogene.

      As one of the relatively few available gallbladder cancer cell lines, OCUG-1 has been examined as a representative hapatobiliary cancer in genome-wide mutation and expression studies. In one such study, Scherer et al. noted that the expression profile of the known primary gallbladder tumor markers is not commonly shared by the gallbladder cancer cell lines and suggested that investigators choose their cellular platforms based not only on the tissue origin of the tumors but also on the driver gene expression patterns underlying the specific mechanisms of tumorigenesis.

      Source
      SCC642 cell line was isolated from the peritoneal effusion of a 43 year old Japanese male patient with malignant gallbladder carcinoma.

      References
      1. Yamada N, Chung Y, Ohtani H, Ikeda T, Onoda N, Sawada T, Nishiguchi Y, Hasuma T, Sowa M. Establishment and characterization of a new human gallbladder carcinoma cell line (OCUG-1) producing TA-4. Int J Oncol. 1997 Jun;10(6):1251-5.
      References
      Product Information
      Components
      • ≥1x106 viable OCUG-1 cells (Catalog No. SCC642). Store in liquid nitrogen.
      Quality LevelMQ100
      Applications
      ApplicationThe OCUG-1 human gallbladder carcinoma cell line has been used to study hapatobiliary cancer in genome-wide mutation and expression studies.
      Key Applications
      • Cell Culture
      Application NotesThis product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@milliporesigma.com.
      Biological Information
      HostHuman
      Cell Line Type
      • Cancer Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assurance• Each vial contains ≥ 1X106 viable cells.
      • Cells are tested negative for infectious diseases by a Essential CLEAR Panel by Charles River Animal Diagnostic Services.
      • Cells are verified to be of human origin and negative for interspecies contamination from mouse, rat, Chinese hamster, Golden Syrian hamster, and nonhuman primate (NHP) as assessed by a Contamination Clear panel by Charles River Animal Diagnostic Services
      • Cells are negative for mycoplasma contamination.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsOCUG-1 cells should be stored in liquid nitrogen. The cells can be cultured for at least 10 passages without significantly affecting cell marker expression and function.
      Packaging Information
      Material Size≥1X10⁶ cells/vial
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      SCC642 04065272001427