538120 Sigma-AldrichNLRP3 Inhibitor, MCC950 - CAS 256373-96-3 - Calbiochem
A cell-potent, bioavailable NLRP3 inflammasome activation inhibitor. Effectively blocks caspase-1 & -11 activation, IL-1β processing and IL-1β & IL-6 secretion.
More>> A cell-potent, bioavailable NLRP3 inflammasome activation inhibitor. Effectively blocks caspase-1 & -11 activation, IL-1β processing and IL-1β & IL-6 secretion. Less<<Synonyms: N-(1,2,3,5,6,7-Hexahydro-s-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide, Sodium, MCC-950, MCC950, Cytokine Release Inhibitory Drug 3, CRID 3, CP-456,773
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Overview
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Key Spec Table
CAS # | Empirical Formula |
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256373-96-3 | C₂₀H₂₃N₂O₅S·Na |
Pricing & Availability
Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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5.38120.0001 |
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Glass bottle | 10 mg |
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Product Information | |
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CAS number | 256373-96-3 |
Form | White powder |
Formulation | Supplied as a sodium salt. |
Hill Formula | C₂₀H₂₃N₂O₅S·Na |
Chemical formula | C₂₀H₂₃N₂O₅S·Na |
Hygroscopic | Hygroscopic |
Reversible | Y |
Quality Level | MQ100 |
Applications |
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Biological Information | |
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Primary Target | NLRP3 |
Purity | ≥97% by HPLC |
Physicochemical Information | |
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Cell permeable | Y |
Dimensions |
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Materials Information |
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Toxicological Information |
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Safety Information according to GHS |
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Safety Information |
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Product Usage Statements |
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Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
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Supplemental Information |
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Specifications |
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Global Trade Item Number | |
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Catalogue Number | GTIN |
5.38120.0001 | 04054839059308 |
Documentation
NLRP3 Inhibitor, MCC950 - CAS 256373-96-3 - Calbiochem SDS
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NLRP3 Inhibitor, MCC950 - CAS 256373-96-3 - Calbiochem Certificates of Analysis
Title | Lot Number |
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538120 |
References
Reference overview |
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Coll, R.C., et al. 2015. Nat. Med. 21, 248. Coll, R.C. and O'Neill, L.A.J. 2011. PLoS ONE. 6, e29539. Laliberte, R.E., et al. 2003. J. Biol. Chem. 278, 16567. Perregaux, D.G., et al. 2001. J. Pharmacol. Exp. Ther. 299, 187. |