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475840 Milrinone - CAS 78415-72-2 - Calbiochem

A cell-permeable, selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC₅₀ = 300 nM).

Milrinone - CAS 78415-72-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1,6-Dihydro-2-methyl-6-oxo-(3,4ʹ-bipyridine)-5-carbonitrile

Primary Target: PDE 3
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      Overview

      Key Spec Table

      CAS #Empirical Formula
      78415-72-2C₁₂H₉N₃O
      Description
      OverviewA cell-permeable, selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC50 = 300 nM). Has positive chronotropic, inotropic, and vasodilatory effects on the heart.
      Catalogue Number475840
      Brand Family Calbiochem®
      Synonyms1,6-Dihydro-2-methyl-6-oxo-(3,4ʹ-bipyridine)-5-carbonitrile
      References
      ReferencesBailey, J.M., et al. 1994. Anesthesiology 81, 616.
      Wilhelm, D., et al. 1992. J. Cardiovasc. Pharmacol. 20, 705.
      Lindgren, S.H., et al. 1990. Acta. Phys. Scand. 140, 209.
      Harrison, S.A., et al. 1986. Mol. Pharmacol. 29, 506.
      Product Information
      CAS number78415-72-2
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₂H₉N₃O
      Chemical formulaC₁₂H₉N₃O
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetPDE 3
      Primary Target IC<sub>50</sub>300 nM against PDE III
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableY
      Safety Information according to GHS
      RTECSDW1762000
      Safety Information
      R PhraseR: 23/24/25

      Toxic by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36/37/39-45

      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      475840 0