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445885 Metastin, Synthetic

A KiSS-1 gene product with 54 amino-acid residues and a C-terminally amidated LRF-motif that acts as a metastasis inhibitor via G-protein-coupled receptors (GPCRs).

Metastin, Synthetic MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: KiSS-1 (68-121), Kisspeptin-54

Primary Target: G-protein-coupled receptors (GPCRs)
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₂₅₈H₄₀₁N₇₉O₇₈
      Description
      Overview

      This product has been discontinued.





      A KiSS-1 gene product with 54 amino-acid residues and a C-terminally amidated LRF-motif that acts as a metastasis inhibitor via G-protein-coupled receptors (GPCRs). Reported to inhibit chemotaxis and invasion of hOT7T175-transfected CHO cells in vitro (IC50 = 50 nM) and attenuates pulmonary metastasis of hOT7T175-transfected B16-BL6 melanomas in vivo. Shown to be a potent and selective agonist of AXOR12 and hOT7T175 (a novel human GPCR). Induces an increase in intracellular Ca2+ levels in CHO/h175 and CHO/AXOR12:Gqi5 cells. Binds to hOT7T175 with high affinity (Ki = 340 pM, determined by competitive binding analysis).
      Catalogue Number445885
      Brand Family Calbiochem®
      SynonymsKiSS-1 (68-121), Kisspeptin-54
      References
      ReferencesKotani, M., et al. 2001. J. Biol. Chem. 276, 34631.
      Ohtaki, T., et al. 2001. Nature 411, 613.
      Muir, A.I., et al. 2001. J. Biol. Chem. 276, 28969.
      Product Information
      ATP CompetitiveN
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₂₅₈H₄₀₁N₇₉O₇₈
      Chemical formulaC₂₅₈H₄₀₁N₇₉O₇₈
      Hygroscopic Hygroscopic
      ReversibleN
      Applications
      Biological Information
      Primary TargetG-protein-coupled receptors (GPCRs)
      Primary Target IC<sub>50</sub>50 nM inhibiting chemotaxis and invasion of hOT7T175-transfected CHO cells in vitro
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceH-Gly-Thr-Ser-Leu-Ser-Pro-Pro-Pro-Glu-Ser-Ser-Gly-Ser-Arg-Gln-Gln-Pro-Gly-Leu-Ser-Ala-Pro-His-Ser-Arg-Gln-Ile-Pro-Ala-Pro-Gln-Gly-Ala-Val-Leu-Val-Gln-Arg-Glu-Lys-Asp-Leu-Pro-Asn-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      445885 0

      Documentation

      Metastin, Synthetic Certificates of Analysis

      TitleLot Number
      445885

      References

      Reference overview
      Kotani, M., et al. 2001. J. Biol. Chem. 276, 34631.
      Ohtaki, T., et al. 2001. Nature 411, 613.
      Muir, A.I., et al. 2001. J. Biol. Chem. 276, 28969.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-August-2008 RFH
      SynonymsKiSS-1 (68-121), Kisspeptin-54
      DescriptionA KiSS-1 gene product with 54 amino acids and a C-terminally amidated LRF-motif that acts as a metastasis inhibitor via G-protein-coupled receptors (GCPRs). Reported to inhibit chemotaxis and invasion of hOT7T175-transfected CHO cells in vitro (IC50 = 50 nM) and attenuates pulmonary metastasis of hOT7T175-transfected B16-BL6 melanomas in vivo. Shown to be a potent and selective agonist of AXOR12 and hOT7T175 (a novel human GPCR). Induces an increase in intracellular Ca2+ levels in CHO/h175 and CHO/AXOR12:Gqi5 cells. Binds to hOT7T175 with high affinity (Ki = 340 pM, determined by competitive binding analysis). Has also been shown to be a ligand for GPR54, an orphan G protein-coupled receptor.
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₅₈H₄₀₁N₇₉O₇₈
      Peptide SequenceH-Gly-Thr-Ser-Leu-Ser-Pro-Pro-Pro-Glu-Ser-Ser-Gly-Ser-Arg-Gln-Gln-Pro-Gly-Leu-Ser-Ala-Pro-His-Ser-Arg-Gln-Ile-Pro-Ala-Pro-Gln-Gly-Ala-Val-Leu-Val-Gln-Arg-Glu-Lys-Asp-Leu-Pro-Asn-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesKotani, M., et al. 2001. J. Biol. Chem. 276, 34631.
      Ohtaki, T., et al. 2001. Nature 411, 613.
      Muir, A.I., et al. 2001. J. Biol. Chem. 276, 28969.