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GF050 Leptin, mouse

Leptin (Anti-Obesity Protein) is the protein product of the ob (obese) gene in mice & appears to be involved in appetite control.

Leptin, mouse MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Key Applications: Cell Culture UniProt Number: P41159, P41160
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GF050
1 mg  
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      Overview

      Key Spec Table

      Key ApplicationsSpeciesSourcePurity
      CULTMouse E.coliGreater than 95% by SDS-PAGE and HPLC analyses
      Description
      Catalogue NumberGF050
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionLeptin, mouse
      OverviewLeptin (Anti-Obesity Protein) is the protein product of the ob (obese) gene in mice and appears to be involved in appetite control. The ob gene is expressed in adipose tissue and is thought to regulate the body's fat stores. Mice with the ob/ob genotype also develop a form of diabetes similar to type II (non-insulin dependent) diabetes. Mouse leptin is a 16 kDa protein containing 147 amino acid residues.
      Product Information
      PresentationLyophilized from 0.1% TFA, no preservatives.
      Quality LevelMQ100
      Applications
      ApplicationLeptin (Anti-Obesity Protein) is the protein product of the ob (obese) gene in mice & appears to be involved in appetite control.
      Key Applications
      • Cell Culture
      Biological Information
      PurityGreater than 95% by SDS-PAGE and HPLC analyses
      SourceE.coli
      Specific ActivityGF050 has been shown to be biologically active in two different mouse obesity models, ob/ob and NZO. Both strains of mice were treated via intraperitoneal injection once daily at a dose of 5 μg leptin/gm of body weight for 14 days. Significant effects on body weight, food consumption, and plasma glucose levels were observed compared to saline-treated controls.
      Entrez Gene SummaryThis gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P41159 # May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.
      SIZE: 167 amino acids; 18641 Da
      SUBUNIT: Interacts with SIGLEC6.
      SUBCELLULAR LOCATION: Secreted.
      DISEASE:SwissProt: P41159 # Defects in LEP may be a cause of autosomal recessive obesity [MIM:601665].
      SIMILARITY: SwissProt: P41159 ## Belongs to the leptin family.
      Stem Cell Type
      • Mesenchymal Stem Cells
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsThe lyophilized powder, though stable at room temperature, is best stored desiccated below 0°C for up to 12 months from date of receipt. After a quick spin, reconstitute the mouse leptin in sterile distilled water to a concentration of 1.0-5.0 mg/mL. After reconstitution maintain at -20°C in undiluted aliquots for up to six months.
      Packaging Information
      Material Size1 mg
      Global Trade Item Number
      Catalogue Number GTIN
      GF050 04053252509469