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428150 Lavendustin A - CAS 125697-92-9 - Calbiochem

A cell-permeable, reversible, and substrate competitive inhibitor of EGF receptor tyrosine kinase and p60c-src with little effect on protein kinase A or protein kinase C.

Lavendustin A - CAS 125697-92-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-Amino-[(N-2,5-dihydroxybenzyl)-Nʹ-2-hydroxybenzyl]salicylic Acid, RG14355

Primary Target: EGF receptor tyrosine kinase
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428150
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
125697-92-9C₂₁H₁₉NO₆

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      Description
      OverviewA cell-permeable, reversible, and substrate competitive inhibitor of EGF receptor tyrosine kinase (IC50 = 11 nM) and p60c-src (IC50 = 500 nM) with little effect on protein kinase A or protein kinase C (IC50 > 200 µM). Also inhibits NMDA-stimulated cGMP production (IC50 = 30 nM). Exhibits anti-proliferative properties. Suppresses the angiogenic action of vascular endothelial growth factor (VEGF) in rats.
      Catalogue Number428150
      Brand Family Calbiochem®
      Synonyms5-Amino-[(N-2,5-dihydroxybenzyl)-Nʹ-2-hydroxybenzyl]salicylic Acid, RG14355
      References
      ReferencesHu, D.E., and Fan, T.-P. 1995. Br. J. Pharmacol. 114, 262.
      Rodriguez, J., et al. 1994. Neuropharmacology 33, 1267.
      Hsu, C.-Y., et al. 1991. J. Biol. Chem. 266, 21105.
      O’Dell, T.J., et al. 1991. Nature 353, 558; Onoda, T., et al. 1989. J. Nat. Prod. 52, 1252.
      Bishop, J.M. 1983. Annu. Rev. Biochem. 52, 307.
      Product Information
      CAS number125697-92-9
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₂₁H₁₉NO₆
      Chemical formulaC₂₁H₁₉NO₆
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetEGF receptor tyrosine kinase
      Primary Target IC<sub>50</sub>11 nM and 500 nM against EGF receptor tyrosine kinase and p60c-src, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      428150-1MG 04055977210545

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Lavendustin A - CAS 125697-92-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Lavendustin A - CAS 125697-92-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      428150

      References

      Reference overview
      Hu, D.E., and Fan, T.-P. 1995. Br. J. Pharmacol. 114, 262.
      Rodriguez, J., et al. 1994. Neuropharmacology 33, 1267.
      Hsu, C.-Y., et al. 1991. J. Biol. Chem. 266, 21105.
      O’Dell, T.J., et al. 1991. Nature 353, 558; Onoda, T., et al. 1989. J. Nat. Prod. 52, 1252.
      Bishop, J.M. 1983. Annu. Rev. Biochem. 52, 307.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-December-2018 JSW
      Synonyms5-Amino-[(N-2,5-dihydroxybenzyl)-Nʹ-2-hydroxybenzyl]salicylic Acid, RG14355
      DescriptionA cell-permeable, reversible, substrate competitive, and potent inhibitor of EGF receptor tyrosine kinase (IC50 = 11 nM) and pp60c-src (IC50 = 500 nM) with little effect on protein kinase A or protein kinase C (IC50 >200 µM). Also inhibits NMDA-stimulated cGMP production (IC50 = 30 nM). Exhibits anti-proliferative properties. Suppresses the angiogenic action of vascular endothelial growth factor in rats.
      FormOff-white solid
      CAS number125697-92-9
      Chemical formulaC₂₁H₁₉NO₆
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO or Ethanol (10 mg/ml). Further dilute with aqueous buffer just prior to use.
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesHu, D.E., and Fan, T.-P. 1995. Br. J. Pharmacol. 114, 262.
      Rodriguez, J., et al. 1994. Neuropharmacology 33, 1267.
      Hsu, C.-Y., et al. 1991. J. Biol. Chem. 266, 21105.
      O’Dell, T.J., et al. 1991. Nature 353, 558; Onoda, T., et al. 1989. J. Nat. Prod. 52, 1252.
      Bishop, J.M. 1983. Annu. Rev. Biochem. 52, 307.