Millipore Sigma Vibrant Logo

428021 Latrunculin A, Latrunculia magnifica - CAS 76343-93-6 - Calbiochem

Latrunculin A, CAS 76343-93-6, is a cell-permeable marine toxin that disrupts microfilament organization in cultured cells by the formation of a 1:1 complex with monomeric G-actin (KD = 200 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: G-actin
View Products on Sigmaaldrich.com
428021
View Pricing & Availability

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
76343-93-6C₂₂H₃₁NO₅S

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
428021-100UG
Retrieving availability...
—
Limited Availability Limited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      		 Plastic ampoule 100 μg
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      —
      Request Pricing
      		 —
      Description
      OverviewA cell-permeable marine toxin that disrupts microfilament organization in cultured cells by the formation of a 1:1 complex with monomeric G-actin (Kd = 200 nM). Also a potent inhibitor of microfilament-mediated processes in sperm, eggs, and embryos. A 1 mM (50 µg/119 µl) solution of Latrunculin A, Latrunculia magnifica Cat. No. 428026 in DMSO is also available.
      Catalogue Number428021
      Brand Family Calbiochem®
      References
      ReferencesAyscough, K.R., et al. 1997. J. Cell Biol. 137, 399.
      Spector, I., et al. 1989. Cell Motil. Cytoskeleton 13, 127.
      Coue, M., et al. 1987. FEBS Lett. 213, 316.
      Schatten, G., et al. 1986. Exp. Cell Res. 166, 191.
      Spector, I., et al. 1983. Science 219, 493.
      Product Information
      CAS number76343-93-6
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₂H₃₁NO₅S
      Chemical formulaC₂₂H₃₁NO₅S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetG-actin
      Primary Target IC<sub>50</sub>Kd = 200 nM in formation of a 1:1 complex with monomeric G-actin
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      428021-100UG 07790788050214

      Documentation

      Latrunculin A, Latrunculia magnifica - CAS 76343-93-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Latrunculin A, Latrunculia magnifica - CAS 76343-93-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      428021

      References

      Reference overview
      Ayscough, K.R., et al. 1997. J. Cell Biol. 137, 399.
      Spector, I., et al. 1989. Cell Motil. Cytoskeleton 13, 127.
      Coue, M., et al. 1987. FEBS Lett. 213, 316.
      Schatten, G., et al. 1986. Exp. Cell Res. 166, 191.
      Spector, I., et al. 1983. Science 219, 493.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision29-March-2024 JSW
      DescriptionA cell-permeable marine toxin from the Red Sea sponge Latrunculia magnifica that disrupts microfilament organization in cultured cells by the formation of a 1:1 complex with monomeric G-actin (Kd = 200 nM). Also a potent inhibitor of microfilament-mediated processes in sperm, eggs, and embryos.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number76343-93-6
      Chemical formulaC₂₂H₃₁NO₅S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      Merck USA index14, 8378
      ReferencesAyscough, K.R., et al. 1997. J. Cell Biol. 137, 399.
      Spector, I., et al. 1989. Cell Motil. Cytoskeleton 13, 127.
      Coue, M., et al. 1987. FEBS Lett. 213, 316.
      Schatten, G., et al. 1986. Exp. Cell Res. 166, 191.
      Spector, I., et al. 1983. Science 219, 493.