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505880 L-745,870 Trihydrochloride - CAS 158985-00-3 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Dopamine D₄ receptor Antagonist, L-745,870 trihydrochloride, L-745870, L745870

Primary Target: D₄
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505880
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Overview

Key Spec Table

CAS #Empirical Formula
158985-00-3C₁₈H₁₉N₄Cl•3HCl

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      		 Glass bottle 10 mg
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      Description
      OverviewSelective D4 receptor antagonist with excellent brain penetration. Displays an affinity (Ki) of 0.4 nM for human D4 receptors with >1000-fold binding selectivity over D2 and D3 receptors. Does not block agonist-induced activation of GIRK currents. It is used frequently in retinal and CNS studies of D4 modulation.
      Catalogue Number505880
      Brand Family Calbiochem®
      SynonymsDopamine D₄ receptor Antagonist, L-745,870 trihydrochloride, L-745870, L745870
      References
      ReferencesLi, H. et al., 2013. J. Neurosci. 33, 3135.
      Pillai, G. et al. 1998. Neuropharmacol. 337, 983.
      Kulagowski, J. et al. 1996. J. Med. Chem. 39, 1941.
      Product Information
      CAS number158985-00-3
      FormOff-white solid
      Hill FormulaC₁₈H₁₉N₄Cl•3HCl
      Chemical formulaC₁₈H₁₉N₄Cl•3HCl
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetD₄
      Primary Target K<sub>i</sub>0.4 nM
      Purity≥99% by HPLC
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      5.05880.0001 04055977263169