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420321 KT5823 - CAS 126643-37-6 - Calbiochem

Highly specific, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase G (Ki = 234 nM).

KT5823 - CAS 126643-37-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PKG Inhibitor VII

Primary Target: PKG
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
126643-37-6C₂₉H₂₅N₃O₅

Pricing & Availability

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420321-100UG
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      420321-50UG
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          Description
          OverviewHighly specific, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase G (Ki = 234 nM).
          Catalogue Number420321
          Brand Family Calbiochem®
          SynonymsPKG Inhibitor VII
          References
          ReferencesGrider, J.R. 1993. Am. J. Physiol. 264, G334.
          Product Information
          CAS number126643-37-6
          ATP CompetitiveY
          FormWhite solid
          Hill FormulaC₂₉H₂₅N₃O₅
          Chemical formulaC₂₉H₂₅N₃O₅
          ReversibleY
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetPKG
          Primary Target K<sub>i</sub>234 nM against protein kinase G
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          420321-100UG 04055977211047
          420321-50UG 04055977211054

          Documentation

          Required Licenses

          Title
          PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

          KT5823 - CAS 126643-37-6 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          KT5823 - CAS 126643-37-6 - Calbiochem Certificates of Analysis

          TitleLot Number
          420321

          References

          Reference overview
          Grider, J.R. 1993. Am. J. Physiol. 264, G334.

          Citations

          Title
        • Mike T. Lin, et al. (2005) Ca2+-activated K+ channel-associated phosphatase and kinase activities during development. American Journal of Physiology Heart and Circulatory Physiology 289, H414-H425.
        • Bing Zhu, Samuel Strada and Troy Stevens. (2005) Cyclic GMP-specific phosphodiesterase 5 regulates growth and apoptosis in pulmonary endothelial cells. American Journal of Physiology Lung Cellular and Molecular Physiology 289, L196-L206.
          		•
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision30-July-2008 RFH
          SynonymsPKG Inhibitor VII
          DescriptionHighly specific cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase G (Ki = 234 nM). Inhibits protein kinase C (Ki = 4.0 µM) and protein kinase A (Ki > 10.0 µM) at higher concentrations.
          FormWhite solid
          CAS number126643-37-6
          Chemical formulaC₂₉H₂₅N₃O₅
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMF or DMSO (1 mg/ml). Further dilute with aqueous buffers just prior to use.
          Storage Protect from light
          -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesGrider, J.R. 1993. Am. J. Physiol. 264, G334.
          Citation
        • Mike T. Lin, et al. (2005) Ca2+-activated K+ channel-associated phosphatase and kinase activities during development. American Journal of Physiology Heart and Circulatory Physiology 289, H414-H425.
        • Bing Zhu, Samuel Strada and Troy Stevens. (2005) Cyclic GMP-specific phosphodiesterase 5 regulates growth and apoptosis in pulmonary endothelial cells. American Journal of Physiology Lung Cellular and Molecular Physiology 289, L196-L206.
          		•