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420126 JAK3 Inhibitor VI - CAS 856436-16-3 - Calbiochem

The JAK3 Inhibitor VI, also referenced under CAS 856436-16-3, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: JAK-3
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420126
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
856436-16-3 C₁₈H₁₃N₃O • MeSO₃H

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420126-5MG
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      Description
      OverviewA cell-permeable 3′-pyridyl oxindole compound that acts as a potent and reversible inhibitor of JAK3 (IC50 = 27 nM)and displays ~16-fold greater selectivity over JAK2. Binds to the enzyme active site and prevents IL-2-induced cellular phosphorylation of JAK3 and STAT5. Inhibits IL-2-induced cell proliferation (IC50 = 760 and 250 nM for mouse CTLL and human T-cells, respectively) and alleviates oxazolone-induced ear odema in mouse with an efficacy comparable to that of Dexamethasone (Cat. No. 265005).
      Catalogue Number420126
      Brand Family Calbiochem®
      References
      ReferencesChen, J., et al. 2006. Bioorg. Med. Chem. Lett. In press.
      Adams, C., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3105.
      Product Information
      CAS number856436-16-3
      ATP CompetitiveN
      FormYellow solid
      Hill Formula C₁₈H₁₃N₃O • MeSO₃H
      Chemical formulaC₁₈H₁₃N₃O • MeSO₃H
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetJAK-3
      Primary Target IC<sub>50</sub>27 nM
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      420126-5MG 04055977188042

      Documentation

      JAK3 Inhibitor VI - CAS 856436-16-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      JAK3 Inhibitor VI - CAS 856436-16-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      420126

      References

      Reference overview
      Chen, J., et al. 2006. Bioorg. Med. Chem. Lett. In press.
      Adams, C., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3105.

      Brochure

      Title
      Pathways and Biomarkers of JAK/STAT Signaling

      Technical Info

      Title
      JAK/STAT Signaling Research Focus
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-January-2010 RFH
      DescriptionA cell-permeable, potent, and reversible inhibitor of Janus kinase 3 (JAK3) (IC50 = 27 nM). Reported to bind to the enzyme active site and prevent IL-2-induced phosphorylation of JAK3 and STAT5. Also reported to inhibit IL-2-induced cell proliferation (IC50 = 760 nM for murine CTLL cells and 250 nM for human T-cells). Shown to alleviate oxazolone-induced ear edema in mice with an efficacy comparable to Dexamethasone (Cat. No. 265005) and displays ~16-fold greater selectivity over JAK2.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number856436-16-3
      Chemical formulaC₁₈H₁₃N₃O • MeSO₃H
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (5 mg/ml) or H₂O (1 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesChen, J., et al. 2006. Bioorg. Med. Chem. Lett. In press.
      Adams, C., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3105.