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420101 JAK3 Inhibitor I - CAS 202475-60-3 - Calbiochem

The JAK3 Inhibitor I, also referenced under CAS 202475-60-3, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-(4ʹ-Hydroxyphenyl)amino-6,7-dimethoxyquinazoline, WHI-P131

Primary Target: Janus family kinase 3
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420101
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
202475-60-3C₁₆H₁₅N₃O₃

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420101-5MG
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      Description
      OverviewA cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (Janus family kinase 3; IC50 = 78 µM). Has no effect on JAK1, JAK2, or Zap/Syk or Src tyrosine kinases. Acts as a potent inhibitor of glioblastoma cell adhesion and migration. Also reported to block thrombin-induced platelet aggregation.
      Catalogue Number420101
      Brand Family Calbiochem®
      Synonyms4-(4ʹ-Hydroxyphenyl)amino-6,7-dimethoxyquinazoline, WHI-P131
      References
      ReferencesTibbles, H.E., et al. 2001. J. Biol. Chem. 276, 17815.
      Sudbeck, E.A., et al. 1999. Clin. Cancer Res. 5, 1569.
      Goodman, P.A., et al. 1998. J. Biol. Chem. 273, 17742.
      Narla, R.K., et al. 1998. Clin. Cancer Res. 4, 2463.
      Product Information
      CAS number202475-60-3
      ATP CompetitiveY
      FormWhite to off-white solid
      Hill FormulaC₁₆H₁₅N₃O₃
      Chemical formulaC₁₆H₁₅N₃O₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetJanus family kinase 3
      Primary Target IC<sub>50</sub>78 µM against Janus family kinase 3
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      420101-5MG 04055977187892

      Documentation

      JAK3 Inhibitor I - CAS 202475-60-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      JAK3 Inhibitor I - CAS 202475-60-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      420101

      References

      Reference overview
      Tibbles, H.E., et al. 2001. J. Biol. Chem. 276, 17815.
      Sudbeck, E.A., et al. 1999. Clin. Cancer Res. 5, 1569.
      Goodman, P.A., et al. 1998. J. Biol. Chem. 273, 17742.
      Narla, R.K., et al. 1998. Clin. Cancer Res. 4, 2463.

      Technical Info

      Title
      JAK/STAT Signaling Research Focus
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-April-2011 RFH
      Synonyms4-(4ʹ-Hydroxyphenyl)amino-6,7-dimethoxyquinazoline, WHI-P131
      DescriptionA cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (Janus family kinase 3) (IC50 = 78 µM). Has no effect on either JAK1, JAK2, Zap/Syk or Src kinases. Blocks thrombin-induced platelet aggregation.
      FormWhite to off-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number202475-60-3
      Chemical formulaC₁₆H₁₅N₃O₃
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesTibbles, H.E., et al. 2001. J. Biol. Chem. 276, 17815.
      Sudbeck, E.A., et al. 1999. Clin. Cancer Res. 5, 1569.
      Goodman, P.A., et al. 1998. J. Biol. Chem. 273, 17742.
      Narla, R.K., et al. 1998. Clin. Cancer Res. 4, 2463.