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371957 Isogranulatimide - CAS 244148-46-7 - Calbiochem

Isogranulatimide, also referenced under CAS 244148-46-7, modulates the biological activity of Chk1 and GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: IGR, Chk2 Inhibitor III, Chk1 Inhibitor III

Primary Target: Chk1
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      244148-46-7C₁₅H₈N₄O₂
      Description
      OverviewA cell-permeable alkaloid containing indole/maleimide/imidazole skeleton that acts as a potent, reversible and ATP-competitive inhibitor of Chk1 (IC50 = 100 nM) and GSK-3β (IC50 = 500 nM). Inhibits G2 DNA damage checkpoint-associated kinases, Chk2, Cdk1, and DNA-PK only at much higher concentrations (IC50 = 3 µM, 10 µM, and 10 µM, respectively). Only minimally affects the activities of a panel of 11 other kinases tested (IC50 ≥ 40 µM). When used in combination with γ-irradiation, it is also reported to selectively arrest the growth of MCF-7 cells lacking p53 function.
      Catalogue Number371957
      Brand Family Calbiochem®
      SynonymsIGR, Chk2 Inhibitor III, Chk1 Inhibitor III
      References
      ReferencesJiang, X., et al. 2004. Mol. Cancer Ther. 3, 1221.
      Roberge, M., et al. 1998. Cancer Res. 58, 5701.
      Product Information
      CAS number244148-46-7
      ATP CompetitiveY
      FormDark red solid
      Hill FormulaC₁₅H₈N₄O₂
      Chemical formulaC₁₅H₈N₄O₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetChk1
      Primary Target IC<sub>50</sub>100 nM, 500 nM, against Chk1 and GSK-3β, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      371957 0

      Documentation

      Isogranulatimide - CAS 244148-46-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Isogranulatimide - CAS 244148-46-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      371957

      References

      Reference overview
      Jiang, X., et al. 2004. Mol. Cancer Ther. 3, 1221.
      Roberge, M., et al. 1998. Cancer Res. 58, 5701.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-December-2009 RFH
      SynonymsIGR, Chk2 Inhibitor III, Chk1 Inhibitor III
      DescriptionA cell-permeable, potent, reversible, and ATP-competitive inhibitor of Chk1 (IC50 = 100 nM) and GSK-3β (IC50 = 500 nM). Inhibits G2 DNA damage checkpoint-associated kinases, Chk2, Cdk1, and DNA-PK only at much higher concentrations (IC50 = 3 µM, 10 µM, and 10 µM, respectively). Only minimally affects the activities of a panel of 11 other kinases tested (IC50 ≥ 40 µM). When used in combination with γ-irradiation, it is also reported to selectively arrest the growth of MCF-7 cells lacking p53 function.
      FormDark red solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number244148-46-7
      Chemical formulaC₁₅H₈N₄O₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesJiang, X., et al. 2004. Mol. Cancer Ther. 3, 1221.
      Roberge, M., et al. 1998. Cancer Res. 58, 5701.