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551476 InSolution™ Q-VD-OPh, Non-O-methylated - Calbiochem

InSolution™ Q-VD-OPh, Non-O-methylated, is a cell-permeable, irreversible, broad-spectrum inhibitor of caspases (IC₅₀ = 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(2-Quinolyl)valyl-aspartyl-(2,6-difluorophenoxy)methyl Ketone

Primary Target: caspase-1
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551476
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Overview

Key Spec Table

Empirical Formula
C₂₆H₂₅F₂N₃O₆

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551476-1MG
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      551476-5MG
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          Description
          OverviewA cell-permeable, irreversible, broad-spectrum caspase inhibitor (IC50 = 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively) with effective antiapoptotic properties against all major caspase-mediated cellular apoptosis pathways. Exhibits no cytotoxic effects even at extremely high concentrations. Shown to reduce ischemic brain damage and stroke-induced programmed cell death in thymus and spleen.
          Catalogue Number551476
          Brand Family Calbiochem®
          SynonymsN-(2-Quinolyl)valyl-aspartyl-(2,6-difluorophenoxy)methyl Ketone
          References
          ReferencesBraun, J.S., et al. 2007. Exp. Neurol. 206, 183.
          Caserta, T.M., et al. 2003. Apoptosis 8, 345.
          Rebbaa, A., et al. 2003. Oncogene 22, 2805.
          Product Information
          ATP CompetitiveN
          FormLiquid
          FormulationSupplied as a 10 mM (1 mg/195 µl) solution in DMSO.
          Hill FormulaC₂₆H₂₅F₂N₃O₆
          Chemical formulaC₂₆H₂₅F₂N₃O₆
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Biological Information
          Primary Targetcaspase-1
          Primary Target IC<sub>50</sub>50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceQ-Val-Asp-CH₂-OPh
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Global Trade Item Number
          Catalogue Number GTIN
          551476-1MG 04055977268898
          551476-5MG 04055977268904