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496000 InSolution™ OM99-2 - CAS 314266-76-7 - Calbiochem

An eight residue peptidomimetic, tight binding transition-state analog inhibitor of human brain memapsin 2.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: EVNLΨAAEF

Primary Target: human brain memapsin 2
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496000
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
314266-76-7C₄₁H₆₄N₈O₁₄

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      		 Plastic ampoule 250 μg
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      Description
      OverviewAn eight residue peptidomimetic, tight binding transition-state analog inhibitor of human brain memapsin 2 (Ki = 1.6 nM, recombinant memapsin 2; Ki = 9.58 nM, recombinant pro-memapsin 2). Also inhibits cathepsin D (Ki = 48 nM). This aspartyl protease inhibitor is designed from the template of the β-secretase site of Swedish β-amyloid precursor protein (APP) with Asp to Ala replacement; also includes a nonhydrolyzable hydroxyethylene isostere between Leu and Ala.
      Catalogue Number496000
      Brand Family Calbiochem®
      SynonymsEVNLΨAAEF
      References
      ReferencesGhosh, A.K., et al. 2001. J. Med. Chem. 44, 2865.
      Turner III, R.T., et al. 2001. Biochemistry 40, 10001.
      Ghosh, A.K., et al. 2000. J. Am. Chem. Soc. 122, 3522.
      Hong, L., et al. 2000. Science 290,150.
      Product Information
      CAS number314266-76-7
      ATP CompetitiveN
      FormLiquid
      FormulationA 1 mM (250µg in 280 µl) solution in DMSO. Supplied as a trifluoroacetate salt.
      Hill FormulaC₄₁H₆₄N₈O₁₄
      Chemical formulaC₄₁H₆₄N₈O₁₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targethuman brain memapsin 2
      Primary Target K<sub>i</sub>1.6 nM against recombinant memapsin 2; 9.58 nM against recombinant pro-memapsin 2; 48 nM against cathepsin D
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceGlu-Val-Asn-Leu-Ψ-Ala-Ala-Glu-Phe [Ψ denotes replacement of CONH by (S)-CH(OH)CH₂]
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      496000-250UG 04055977199826

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      InSolution™ OM99-2 - CAS 314266-76-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ OM99-2 - CAS 314266-76-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      496000

      References

      Reference overview
      Ghosh, A.K., et al. 2001. J. Med. Chem. 44, 2865.
      Turner III, R.T., et al. 2001. Biochemistry 40, 10001.
      Ghosh, A.K., et al. 2000. J. Am. Chem. Soc. 122, 3522.
      Hong, L., et al. 2000. Science 290,150.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-August-2008 RFH
      SynonymsEVNLΨAAEF
      DescriptionA peptidomimetic, highly potent, tight-binding transition-state analog inhibitor of human brain β-secretase (Ki = 1.6 nM, recombinant memapsin-2; Ki = 9.58 nM, recombinant pro-memapsin 2). Designed from the template of the β-secretase site of Swedish β-amyloid precursor protein (APP) with Asp to Ala replacement. Includes a nonhydrolyzable hydroxyethylene isostere between Leu and Ala. Also reported to inhibit cathepsin D at higher levels (Ki = 48 nM).
      FormLiquid
      FormulationA 1 mM (250µg in 280 µl) solution in DMSO. Supplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number314266-76-7
      Chemical formulaC₄₁H₆₄N₈O₁₄
      Peptide SequenceGlu-Val-Asn-Leu-Ψ-Ala-Ala-Glu-Phe [Ψ denotes replacement of CONH by (S)-CH(OH)CH₂]
      Structure formulaStructure formula
      Purity≥90% by HPLC
      Storage Protect from moisture
      Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.
      Toxicity Standard Handling
      ReferencesGhosh, A.K., et al. 2001. J. Med. Chem. 44, 2865.
      Turner III, R.T., et al. 2001. Biochemistry 40, 10001.
      Ghosh, A.K., et al. 2000. J. Am. Chem. Soc. 122, 3522.
      Hong, L., et al. 2000. Science 290,150.