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431050 InSolution™ Leptomycin B, Streptomyces sp. - CAS 87081-35-4 - Calbiochem

InSolution™ Leptomycin B, Streptomyces sp., CAS 87081-35-4, is a 20 µg/ml solution in ethanol. An antifungal agent that blocks nuclear export by impairing the function of nuclear export factor CRM1.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: LMB, Chromosome Region Maintenance 1 Protein Inhibitor I, CRM1 Inhibitor I, Exportin 1 Inhibitor I, XPO1 Inhibitor I

Primary Target: HIV-1 replication in primary human monocytes
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      87081-35-4C₃₃H₄₈O₆
      Description
      OverviewAn antifungal antibiotic that acts as an inhibitor of nuclear export because of its ability to interact with and impair the function of the nuclear export factor CRM1. It is about twice as potent as Leptomycin A (Cat. No. 431051) in inhibiting nucleocytoplasmic translocation of Rev, blocks the Rev-dependent export of mRNA into cytoplasm, and suppresses HIV-1 replication in primary human monocytes (IC50 = 600 pM). In addition, LMB effectively induces the accumulation of p53 in the nucleus of normal fibroblasts as well as protects p53 from Mdm2-mediated ubiquitination and degradation.
      Caution! Product contains volatile liquid. Keep product cold at all times.
      Catalogue Number431050
      Brand Family Calbiochem®
      SynonymsLMB, Chromosome Region Maintenance 1 Protein Inhibitor I, CRM1 Inhibitor I, Exportin 1 Inhibitor I, XPO1 Inhibitor I
      References
      ReferencesKau, T.R., and Silver, P.A. 2003. Drug Discov. Today 8, 78.
      Menendez, S., et al. 2003. Br. J. Cancer 88, 636.
      Xirodimas, D.P., et al. 2001. Exp. Cell Res. 270, 66.
      Kudo, N., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 9112.
      Lain, S., et al. 1999. Exp. Cell Res. 248, 457.
      Wolff, B., et al. 1997. Chem. Biol. 4, 139.
      Yoshida, M., et al. 1990. Exp. Cell Res. 187, 150.
      Komiyama, K., et al. 1985. J. Antibiot. 38, 427.
      Product Information
      CAS number87081-35-4
      ATP CompetitiveN
      FormLiquid
      FormulationSupplied at 20 µg/ml (5 µg in 250 µl) in absolute ethanol
      Hill FormulaC₃₃H₄₈O₆
      Chemical formulaC₃₃H₄₈O₆
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationInSolution™ Leptomycin B, Streptomyces sp., CAS 87081-35-4, is a 20 µg/ml solution in ethanol. An antifungal agent that blocks nuclear export by impairing the function of nuclear export factor CRM1.
      Biological Information
      Primary TargetHIV-1 replication in primary human monocytes
      Primary Target IC<sub>50</sub>600 pM in suppressing HIV-1 replication in primary human monocytes
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Flammable
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage ≤ -70°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and freeze (-70°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      431050 0

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      InSolution™ Leptomycin B, Streptomyces sp. - CAS 87081-35-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ Leptomycin B, Streptomyces sp. - CAS 87081-35-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      431050

      References

      Reference overview
      Kau, T.R., and Silver, P.A. 2003. Drug Discov. Today 8, 78.
      Menendez, S., et al. 2003. Br. J. Cancer 88, 636.
      Xirodimas, D.P., et al. 2001. Exp. Cell Res. 270, 66.
      Kudo, N., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 9112.
      Lain, S., et al. 1999. Exp. Cell Res. 248, 457.
      Wolff, B., et al. 1997. Chem. Biol. 4, 139.
      Yoshida, M., et al. 1990. Exp. Cell Res. 187, 150.
      Komiyama, K., et al. 1985. J. Antibiot. 38, 427.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-September-2007 RFH
      SynonymsLMB, Chromosome Region Maintenance 1 Protein Inhibitor I, CRM1 Inhibitor I, Exportin 1 Inhibitor I, XPO1 Inhibitor I
      DescriptionAn unsaturated, branched-chain fatty acid with a terminal lactone ring that acts as a potent inhibitor of CRM-1-mediated (exportin-1) nuclear export. Exhibits antibiotic, anti-fungal, and anti-tumor properties and blocks the progression of the cell cycle at the G1 and G2 phases. Shown to inhibit nucleo-cytoplasmic translocation of Rev at nanomolar concentrations and block Rev-dependent export of mRNA into the cytoplasm. Also shown to suppress HIV-1 replication in primary human monocytes (IC50 = 600 pM). Effectively induces the accumulation of p53 in the nucleus of normal fibroblasts and protects p53 from Mdm2-mediated ubiquitination and degradation. Useful for studies involving nuclear localization and protein trafficking in eukaryotic cells.

      Caution! Product contains volatile liquid. Keep product cold at all times.
      FormLiquid
      FormulationSupplied at 20 µg/ml (5 µg in 250 µl) in absolute ethanol
      Intert gas (Yes/No) Packaged under inert gas
      CAS number87081-35-4
      Chemical formulaC₃₃H₄₈O₆
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Storage Protect from light
      ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and freeze (-70°C).
      Toxicity Flammable
      ReferencesKau, T.R., and Silver, P.A. 2003. Drug Discov. Today 8, 78.
      Menendez, S., et al. 2003. Br. J. Cancer 88, 636.
      Xirodimas, D.P., et al. 2001. Exp. Cell Res. 270, 66.
      Kudo, N., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 9112.
      Lain, S., et al. 1999. Exp. Cell Res. 248, 457.
      Wolff, B., et al. 1997. Chem. Biol. 4, 139.
      Yoshida, M., et al. 1990. Exp. Cell Res. 187, 150.
      Komiyama, K., et al. 1985. J. Antibiot. 38, 427.